(Q34303709)

1 August 2017

title

Induced pluripotent stem cells: the new patient? (English)

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1 August 2017

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Milena Bellin

1

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Christine Mummery

object named as

Christine L Mummery

series ordinal

4

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Fred Gage

series ordinal

3

object named as

Fred H Gage

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1 August 2017

2

Maria C Marchetto

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1 August 2017

publication date

4 October 2012

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Nature Reviews Molecular Cell Biology

1 August 2017

published in

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1 August 2017

volume

13

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1 August 2017

issue

11

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1 August 2017

page(s)

713-726

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Diagnosing the decline in pharmaceutical R&D efficiency

1 August 2017

cites work

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31 March 2020

2011 FDA drug approvals

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

31 March 2020

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Induced pluripotent stem cell lines derived from human somatic cells

31 March 2020

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Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming

31 March 2020

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Specification of neuronal and glial subtypes from human pluripotent stem cells

31 March 2020

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Harnessing the potential of induced pluripotent stem cells for regenerative medicine

31 March 2020

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

31 March 2020

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Induced pluripotency: history, mechanisms, and applications

31 March 2020

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The promise of induced pluripotent stem cells in research and therapy

31 March 2020

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Methods for making induced pluripotent stem cells: reprogramming à la carte

31 March 2020

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Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

31 March 2020

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Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.

31 March 2020

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Marked differences in differentiation propensity among human embryonic stem cell lines

31 March 2020

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Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development

31 March 2020

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Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility

31 March 2020

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Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells

31 March 2020

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Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts

31 March 2020

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Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells

31 March 2020

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Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

31 March 2020

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Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview

31 March 2020

1 reference

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells.

31 March 2020

1 reference

NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.

31 March 2020

1 reference

An engineered cardiac reporter cell line identifies human embryonic stem cell-derived myocardial precursors

31 March 2020

1 reference

Identification and selection of cardiomyocytes during human embryonic stem cell differentiation

31 March 2020

1 reference

A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives.

31 March 2020

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Generation of human embryonic stem cell reporter lines expressing GFP specifically in neural progenitors

31 March 2020

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High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.

31 March 2020

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Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells

31 March 2020

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Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

31 March 2020

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Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models

31 March 2020

1 reference

Nuclear plakoglobin is essential for differentiation of cardiac progenitor cells to adipocytes in arrhythmogenic right ventricular cardiomyopathy

31 March 2020

1 reference

Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart

31 March 2020

1 reference

Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology

31 March 2020

1 reference

Nanowired three-dimensional cardiac patches

31 March 2020

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Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development

31 March 2020

1 reference

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

31 March 2020

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Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.

31 March 2020

1 reference

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

31 March 2020

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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease

31 March 2020

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Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia

31 March 2020

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Development of functional human embryonic stem cell-derived neurons in mouse brain

31 March 2020

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Restricted ethnic diversity in human embryonic stem cell lines

31 March 2020

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High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

31 March 2020

1 reference

The dark side of induced pluripotency

31 March 2020

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Induced pluripotent stem cells--a cautionary note

31 March 2020

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Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells

31 March 2020

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Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

31 March 2020

1 reference

Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs

31 March 2020

1 reference

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors

31 March 2020

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A method for genetic modification of human embryonic stem cells using electroporation

31 March 2020

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Generation of induced pluripotent stem cells using recombinant proteins

31 March 2020

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A TALE nuclease architecture for efficient genome editing

31 March 2020

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Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

31 March 2020

1 reference

The International HapMap Project

31 March 2020

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Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

31 March 2020

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Disease-specific induced pluripotent stem cells

31 March 2020

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Strategies for homeostatic stem cell self-renewal in adult tissues

31 March 2020

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Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation

31 March 2020

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Patient-specific induced pluripotent stem-cell models for long-QT syndrome

31 March 2020

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Modelling the long QT syndrome with induced pluripotent stem cells

31 March 2020

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Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

31 March 2020

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Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

31 March 2020

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Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

31 March 2020

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In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells

31 March 2020

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Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β-adrenergic stimulation

31 March 2020

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Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease

31 March 2020

1 reference

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

31 March 2020

1 reference

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

31 March 2020

1 reference

Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells

31 March 2020

1 reference

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

31 March 2020

1 reference

Modelling schizophrenia using human induced pluripotent stem cells

31 March 2020

1 reference

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

31 March 2020

1 reference

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

31 March 2020

1 reference

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

31 March 2020

1 reference

Pre-mRNA splicing and human disease

31 March 2020

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Erosion of dosage compensation impacts human iPSC disease modeling

31 March 2020

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Stem cells. Diseases in a dish take off

31 March 2020

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Somatic coding mutations in human induced pluripotent stem cells

31 March 2020

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Transcriptional signature and memory retention of human-induced pluripotent stem cells

31 March 2020

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Meta-analysis of the heterogeneity of X chromosome inactivation in human pluripotent stem cells.

31 March 2020

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Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

31 March 2020

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A map of human genome variation from population-scale sequencing

31 March 2020

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Virus-free induction of pluripotency and subsequent excision of reprogramming factors

31 March 2020

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Transgene-free production of pluripotent stem cells using piggyBac transposons

31 March 2020

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Induced pluripotent stem cells generated without viral integration

31 March 2020

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Human induced pluripotent stem cells free of vector and transgene sequences

31 March 2020

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Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

31 March 2020

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Reprogramming of mouse and human cells to pluripotency using mature microRNAs.

31 March 2020

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Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins

31 March 2020

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Reprogramming of human primary somatic cells by OCT4 and chemical compounds

31 March 2020

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Vitamin C enhances the generation of mouse and human induced pluripotent stem cells

31 March 2020

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Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.

31 March 2020

1 reference

Complete genetic correction of ips cells from Duchenne muscular dystrophy

31 March 2020

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Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells

31 March 2020

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Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients

31 March 2020

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Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C

31 March 2020

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Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders

31 March 2020

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Generation of pluripotent stem cells from patients with type 1 diabetes

31 March 2020

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Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells

31 March 2020

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Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

31 March 2020

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Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa

31 March 2020

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Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells.

31 March 2020

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Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients

31 March 2020

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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

31 March 2020

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Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.

31 March 2020

1 reference

A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal stem cell defects

31 March 2020

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Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

31 March 2020

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Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)

31 March 2020

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LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

31 March 2020

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Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

31 March 2020

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Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions

31 March 2020

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Modeling retinal degeneration using patient-specific induced pluripotent stem cells

31 March 2020

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L1 retrotransposition in neurons is modulated by MeCP2.

31 March 2020

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Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin

31 March 2020

1 reference

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting

31 March 2020

1 reference

Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells

31 March 2020

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The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

31 March 2020

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Neuronal properties, in vivo effects, and pathology of a Huntington's disease patient-derived induced pluripotent stem cells

31 March 2020

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Signaling defects in iPSC-derived fragile X premutation neurons

31 March 2020

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Drug screening for ALS using patient-specific induced pluripotent stem cells

31 March 2020

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Disease characterization using LQTS-specific induced pluripotent stem cells

31 March 2020

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Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome

31 March 2020

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Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency

31 March 2020

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Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

31 March 2020

1 reference

Modeling familial Alzheimer's disease with induced pluripotent stem cells

31 March 2020

1 reference

Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model

31 March 2020

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Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

31 March 2020

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CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.

31 March 2020

1 reference

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

31 March 2020

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Engineering of human pluripotent stem cells by AAV-mediated gene targeting

31 March 2020

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Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

31 March 2020

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Induced pluripotent stem cells from a spinal muscular atrophy patient

31 March 2020

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Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.

31 March 2020

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Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation

31 March 2020

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A functionally characterized test set of human induced pluripotent stem cells

31 March 2020

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Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

31 March 2020

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Conversion of mouse and human fibroblasts into functional spinal motor neurons

31 March 2020

1 reference

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells

31 March 2020

1 reference

Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing.

31 March 2020

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Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia

31 March 2020

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IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients

31 March 2020

1 reference

Preparation of uniaxial multichannel silk fibroin scaffolds for guiding primary neurons.

31 March 2020

1 reference

Transgene excision has no impact on in vivo integration of human iPS derived neural precursors

31 March 2020

1 reference

Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells

31 March 2020

1 reference

Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification

31 March 2020

1 reference

12 December 2020

Survival and differentiation of transplanted neural stem cells derived from human induced pluripotent stem cells in a rat stroke model

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12 December 2020

Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy.

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12 December 2020

Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes

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12 December 2020

Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient

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12 December 2020

Identifiers

DOI

10.1038/NRM3448

1 reference

Dimensions Publication ID

1 August 2017

1019616486

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