(Q36037969)

English

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia

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scholarly article

1 reference

Europe PubMed Central

11 August 2017

Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia (English)

1 reference

Europe PubMed Central

11 August 2017

catecholaminergic polymorphic ventricular tachycardia

0 references

1 reference

based on heuristic

inferred from title

ventricular tachycardia

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based on heuristic

inferred from title

Alessandra Moretti

2

object named as

Alessandra Moretti

1 reference

Europe PubMed Central

11 August 2017

Daniel Sinnecker

object named as

Daniel Sinnecker

14

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object named as

Laura Iop

4

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object named as

Milena Bellin

6

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Karl-Ludwig Laugwitz

17

object named as

Karl-Ludwig Laugwitz

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Europe PubMed Central

11 August 2017

author name string

Christian B Jung

1

1 reference

Europe PubMed Central

11 August 2017

Michael Mederos y Schnitzler

3

1 reference

Europe PubMed Central

11 August 2017

Ursula Storch

5

1 reference

Europe PubMed Central

11 August 2017

Tatjana Dorn

7

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Europe PubMed Central

11 August 2017

Sandra Ruppenthal

8

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Europe PubMed Central

11 August 2017

Sarah Pfeiffer

9

1 reference

Europe PubMed Central

11 August 2017

Alexander Goedel

10

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Europe PubMed Central

11 August 2017

Ralf J Dirschinger

11

1 reference

Europe PubMed Central

11 August 2017

Melchior Seyfarth

12

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Europe PubMed Central

11 August 2017

Jason T Lam

13

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Europe PubMed Central

11 August 2017

Thomas Gudermann

15

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Europe PubMed Central

11 August 2017

Peter Lipp

16

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Europe PubMed Central

11 August 2017

publication date

25 January 2012

1 reference

Europe PubMed Central

11 August 2017

EMBO Molecular Medicine

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Europe PubMed Central

11 August 2017

4

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Europe PubMed Central

11 August 2017

180-191

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Europe PubMed Central

11 August 2017

3

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Europe PubMed Central

11 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3376852/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Investigating monogenic and complex diseases with pluripotent stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Ryanodine receptors: structure, expression, molecular details, and function in calcium release.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Patient-specific induced pluripotent stem-cell models for long-QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

From the ryanodine receptor to cardiac arrhythmias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Mechanisms and clinical management of inherited channelopathies: long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Ryanodine receptor and calsequestrin in arrhythmogenesis: what we have learnt from genetic diseases and transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Reversing advanced heart failure by targeting Ca2+ cycling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Exercise-induced ventricular arrhythmias in patients with no structural cardiac disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Macromolecular complexes regulating cardiac ryanodine receptor function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Dantrolene--a review of its pharmacology, therapeutic use and new developments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Cardiac calcium signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Postulated role of inter-domain interaction within the ryanodine receptor in Ca(2+) channel regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

A new generation of Ca2+ indicators with greatly improved fluorescence properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

2 October 2017

Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

11 July 2018

Probing a putative dantrolene-binding site on the cardiac ryanodine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

11 July 2018

Dantrolene stabilizes domain interactions within the ryanodine receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

23 September 2018

Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3376852

23 September 2018

Sarcoplasmic Reticulum Ca2+ Release Causes Myocyte Depolarization : Underlying Mechanism and Threshold for Triggered Action Potentials

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201100194

21 January 2018

Postulated role of interdomain interaction within the ryanodine receptor in Ca(2+) channel regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22174035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of calsequestrin 2 causes severe forms of catecholaminergic polymorphic ventricular tachycardia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22174035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22174035

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/EMMM.201100194

1 reference

Europe PubMed Central

11 August 2017

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Europe PubMed Central

11 August 2017

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Europe PubMed Central

11 August 2017

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