(Q34306388)

1 August 2017

title

Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity (English)

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1 August 2017

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Stephanie M Martinez

1

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1 August 2017

Blair U Bradford

2

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1 August 2017

Valerie Y Soldatow

3

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1 August 2017

Oksana Kosyk

4

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1 August 2017

Amelia Sandot

5

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1 August 2017

Rafal Witek

6

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1 August 2017

Robert Kaiser

7

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1 August 2017

Todd Stewart

8

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1 August 2017

Kirsten Amaral

9

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1 August 2017

Kimberly Freeman

10

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1 August 2017

Chris Black

11

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1 August 2017

Edward L LeCluyse

12

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1 August 2017

Stephen S Ferguson

13

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1 August 2017

Ivan Rusyn

14

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1 August 2017

publication date

24 September 2010

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Toxicology and Applied Pharmacology

1 August 2017

published in

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1 August 2017

volume

249

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1 August 2017

issue

3

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1 August 2017

page(s)

208-216

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In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

1 August 2017

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Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

6 July 2018

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6 July 2018

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6 July 2018

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Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations

6 July 2018

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Genome-level analysis of genetic regulation of liver gene expression networks

6 July 2018

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Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening

6 July 2018

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In silico pharmacogenetics of warfarin metabolism.

6 July 2018

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Capturing complex 3D tissue physiology in vitro

6 July 2018

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Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system

6 July 2018

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A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

6 July 2018

1 reference

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Idiosyncratic drug hepatotoxicity

6 July 2018

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New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures

6 July 2018

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Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors

6 July 2018

1 reference

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Rho GTPases in cell biology

6 July 2018

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Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

In vitro models to study hepatotoxicity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

6 July 2018

1 reference

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Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics

6 July 2018

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Peroxisome proliferators do not increase DNA synthesis in purified rat hepatocytes

6 July 2018

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Peroxisome proliferator-activated receptor alpha is restricted to hepatic parenchymal cells, not Kupffer cells: implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis.

6 July 2018

1 reference

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Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation

6 July 2018

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

6 July 2018

1 reference

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Role of kupffer cells in peroxisome proliferator-induced hepatocyte proliferation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Reestablishment of cell polarity of rat hepatocytes in primary culture

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Cell adhesion molecules in liver function and pattern formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Microscale culture of human liver cells for drug development.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Prediction of rodent carcinogenesis: an evaluation of prechronic liver lesions as forecasters of liver tumors in NTP carcinogenicity studies

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2980592

Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver

28 October 2018

1 reference

12 December 2020

Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the presence of hepatocyte growth factor and epidermal growth factor

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12 December 2020

Cell shape, cell-cell contact, cell-extracellular matrix contact and cell polarity are all required for the maximum induction of CYP2B1 and CYP2B2 gene expression by phenobarbital in adult rat cultured hepatocytes

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12 December 2020

An in vitro approach to the study of target organ toxicity of drugs and chemicals

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12 December 2020

Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity

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12 December 2020

Cryopreservation of rat and mouse hepatocytes. II. Assessment of metabolic capacity using testosterone metabolism

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12 December 2020

Differential protein binding and transcriptional activities of HNF-4 elements in three closely related CYP2C genes

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12 December 2020

10.1016/J.TAAP.2010.09.012

Identifiers

DOI

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1 August 2017

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1 August 2017

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