(Q35062472)

6 August 2017

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title

Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors (English)

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6 August 2017

Taro E Akiyama

1

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6 August 2017

Frank J Gonzalez

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

1 February 2003

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6 August 2017

number of pages

12

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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6 August 2017

volume

1619

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6 August 2017

issue

3

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6 August 2017

page(s)

223-234

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Constitutive expression of hepatic cytochrome P450 genes

6 August 2017

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7 January 2021

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7 January 2021

Impaired energy homeostasis in C/EBP alpha knockout mice

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7 January 2021

Synergistic activation of the Atlantic salmon hepatocyte nuclear factor (HNF) 1 promoter by the orphan nuclear receptors HNF4 and chicken ovalbumin upstream promoter transcription factor I (COUP-TFI)

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7 January 2021

Hepatocyte nuclear factor 4 (HNF4) binding sites in the salmon HNF1 promoter

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7 January 2021

An enhancer element 6 kb upstream of the mouse HNF4alpha1 promoter is activated by glucocorticoids and liver-enriched transcription factors

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7 January 2021

Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse

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7 January 2021

HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.

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7 January 2021

A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice

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7 January 2021

Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

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7 January 2021

Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene

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7 January 2021

Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoter

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7 January 2021

Identification of positive and negative regulatory elements of the human cytochrome P4501A2 (CYP1A2) gene

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7 January 2021

In vivo and in vitro regulation of sterol 27-hydroxylase in the liver during the acute phase response. potential role of hepatocyte nuclear factor-1.

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7 January 2021

Down-regulation of the rat hepatic sterol 27-hydroxylase gene by bile acids in transfected primary hepatocytes: possible role of hepatic nuclear factor 1alpha

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7 January 2021

Understanding the role of xenobiotic-metabolism in chemical carcinogenesis using gene knockout mice

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7 January 2021

The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis

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7 January 2021

Role of CYP2E1 in the hepatotoxicity of acetaminophen

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7 January 2021

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice

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7 January 2021

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

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7 January 2021

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus

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7 January 2021

Maturity-onset diabetes of the young (MODY) at least ten times more common in Europe than previously assumed?

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7 January 2021

Different expression of hepatic and renal cytochrome P450s between the streptozotocin-induced diabetic mouse and rat.

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7 January 2021

Cytochrome P450, peroxisome proliferation, and cytoplasmic fatty acid-binding protein content in liver, heart and kidney of the diabetic rat

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7 January 2021

Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in diabetic rat liver

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7 January 2021

Role of peroxisomes in mammalian metabolism

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7 January 2021

Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Suppression of sterol 12alpha-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism

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7 January 2021

The generalized aminoaciduria seen in patients with hepatocyte nuclear factor-1alpha mutations is a feature of all patients with diabetes and is associated with glucosuria.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Sulphonylurea-induced hypoglycaemia in type 2 diabetes mellitus: a review

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7 January 2021

Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: evidence for pharmacogenetics in diabetes

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7 January 2021

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

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7 January 2021

Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4.

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7 January 2021

Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α

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7 January 2021

Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells

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7 January 2021

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

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7 January 2021

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

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7 January 2021

Defective ureagenesis in mice carrying a liver-specific disruption of hepatocyte nuclear factor 4alpha (HNF4alpha ). HNF4alpha regulates ornithine transcarbamylase in vivo

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7 January 2021

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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7 January 2021

DNA binding and transcription activation specificity of hepatocyte nuclear factor 4

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7 January 2021

Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions

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7 January 2021

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver

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7 January 2021

Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression

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7 January 2021

Hepatocyte nuclear factor 4-mediated activation of rat CYP3A1 gene and its modes of modulation by apolipoprotein AI regulatory protein I and v-ErbA-related protein 3.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Transactivation of the rat CYP2C13 gene promoter involves HNF-1, HNF-3, and members of the orphan receptor subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Characterization of orphan nuclear receptor binding elements in sex-differentiated members of the CYP2C gene family expressed in rat liver

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

The CYP2 A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis

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7 January 2021

Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4

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7 January 2021

A transcriptional hierarchy involved in mammalian cell-type specification

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7 January 2021

Analysis of the rat hepatocyte nuclear factor (HNF) 1 gene promoter: synergistic activation by HNF4 and HNF1 proteins

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7 January 2021

Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression

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7 January 2021

Differential protein binding and transcriptional activities of HNF-4 elements in three closely related CYP2C genes

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7 January 2021

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array.

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7 January 2021

The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.

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7 January 2021

Characterization of the human cytochrome P4502D6 promoter. A potential role for antagonistic interactions between members of the nuclear receptor family

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7 January 2021

Contribution of hepatocyte nuclear factor-4 to down-regulation of CYP2D6 gene expression by nitric oxide

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7 January 2021

TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins

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7 January 2021

DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally

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7 January 2021

Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP

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7 January 2021

Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP

1 reference

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7 January 2021

Role of the liver-enriched transcription factor DBP in expression of the cytochrome P450 CYP2C6 gene

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7 January 2021

Biological role of the CCAAT/enhancer-binding protein family of transcription factors

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7 January 2021

The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins

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7 January 2021

Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

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7 January 2021

Transcriptional regulation of the CYP2B1 and CYP2B2 genes by C/EBP-related proteins

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7 January 2021

The CYP2B1 proximal promoter contains a functional C/EBP regulatory element

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7 January 2021

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins

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7 January 2021

CYP2B1 is regulated by C/EBP alpha and C/EBP delta inlung epithelial cells

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7 January 2021

The nuclear receptor superfamily: the second decade

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7 January 2021

Orphan nuclear receptors: from gene to function

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7 January 2021

Use of the nuclear receptor PXR to predict drug interactions

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7 January 2021

Interdomain communication regulating ligand binding by PPAR-gamma

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7 January 2021

Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress

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7 January 2021

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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7 January 2021

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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7 January 2021

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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7 January 2021

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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7 January 2021

Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

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7 January 2021

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

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7 January 2021

Hormones and resistance

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7 January 2021

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

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7 January 2021

Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues

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7 January 2021

A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Cytochrome P-450 3A4: regulation and role in drug metabolism

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

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7 January 2021

6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

1 reference

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7 January 2021

Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5beta-cholestane-3alpha,7alpha,12alpha-triol in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Molecular pathogenesis of cholestasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

The suppressive effect of the catatoxic steroid, pregnenolone-16alpha-carbonitrile, on liver microsomal cholesterol-7alpha-hydroxlyase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Effects of pregnenolone‐16α‐carbonitrile on the metabolism of cholesterol in rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Activation by diverse xenochemicals of the 51-base pair phenobarbital-responsive enhancer module in the CYP2B10 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Phenobarbital induction of CYP2B1/2 in primary hepatocytes: endocrine regulation and evidence for a single pathway for multiple inducers

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

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7 January 2021

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

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7 January 2021

Identification of a nuclear receptor that is activated by farnesol metabolites

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Nuclear orphan receptors control cholesterol catabolism.

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Identification of a nuclear receptor for bile acids

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Bile acids: natural ligands for an orphan nuclear receptor

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7 January 2021

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

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7 January 2021

FXR, a bile acid receptor and biological sensor

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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

1 reference

7 January 2021

Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Molecular cloning and characterization of the murine bile salt export pump

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900480-4

7 January 2021

10.1016/S0304-4165(02)00480-4

Identifiers

DOI

1 reference

6 August 2017

1 reference