(Q34309555)

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Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles.

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14 February 2020

Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles (English)

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14 February 2020

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Leishmania major

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based on heuristic

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1

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14 February 2020

4

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14 February 2020

Tanja Schirmeister

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14 February 2020

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Heidrun Moll

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14 February 2020

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Caroline Schad

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14 February 2020

Christin Glowa

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14 February 2020

Katja Thomale

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14 February 2020

Johannes K Schnitzer

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14 February 2020

Martina Schultheis

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14 February 2020

Norbert Schaschke

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14 February 2020

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20 September 2010

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14 February 2020

Antimicrobial Agents and Chemotherapy

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14 February 2020

54

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14 February 2020

12

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14 February 2020

5028-5041

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14 February 2020

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2981265/fullTextXML

based on heuristic

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Cooperation between apoptotic and viable metacyclics enhances the pathogenesis of Leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Leishmaniasis: current treatment and prospects for new drugs and vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

1 reference

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6 July 2018

Antileishmanial activity mediated by apoptosis and structure-based target study of peganine hydrochloride dihydrate: an approach for rational drug design

1 reference

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6 July 2018

Autophagy-physiology and pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Aziridine-2,3-dicarboxylates, peptidomimetic cysteine protease inhibitors with antileishmanial activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Inhibitors of cysteine proteases

1 reference

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6 July 2018

Synthesis and antileishmanial activities of novel 3-substituted quinolines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Cysteine peptidases as virulence factors of Leishmania

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Cysteine protease inhibitors containing small rings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis.

1 reference

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6 July 2018

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

The induction of autophagic vacuoles and the unique endocytic compartments, C-shaped multivesicular bodies, in GH4C1 cells after treatment with 17beta-estradiol, insulin and EGF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Cysteine protease inhibitors as chemotherapy: lessons from a parasite target

1 reference

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6 July 2018

Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Switch of CD4+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

6 July 2018

Generation, culture and flow-cytometric characterization of primary mouse macrophages.

1 reference

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28 October 2018

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

28 October 2018

Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

28 October 2018

Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

28 October 2018

Theoretical studies about the influence of different ring substituents on the nucleophilic ring opening of three-membered heterocycles and possible implications for the mechanisms of cysteine protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

28 October 2018

Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

28 October 2018

Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

28 October 2018

Apoptotic death in Leishmania donovani promastigotes in response to respiratory chain inhibition: complex II inhibition results in increased pentamidine cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

28 October 2018

Leishmania (Leishmania) amazonensis: differential expression of proteinases and cell-surface polypeptides in avirulent and virulent promastigotes

1 reference

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28 October 2018

Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?

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28 October 2018

On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981265

28 October 2018

Programmed cell death in the unicellular protozoan parasite Leishmania

1 reference

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28 October 2018

Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response.

1 reference

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28 October 2018

Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana.

1 reference

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28 October 2018

Aziridide-Based Inhibitors of Cathepsin L: Synthesis, Inhibition Activity, and Docking Studies

1 reference

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1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of cathepsin B-like cysteine proteases from Leishmania donovani complex. Evidence for the activation of latent transforming growth factor beta

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New Peptidic Cysteine Protease Inhibitors Derived from the Electrophilic α-Amino Acid Aziridine-2,3-dicarboxylic Acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/20855728

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based on heuristic

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Inhibition of cysteine proteases by peptides containing aziridine-2,3-dicarboxylic acid building blocks

1 reference

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based on heuristic

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Rational Design of Aziridine-Containing Cysteine Protease Inhibitors with Improved Potency: Studies on Inhibition Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20855728

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00327-10

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Europe PubMed Central

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14 February 2020

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14 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20855728%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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