(Q34311608)

1 August 2017

title

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells (English)

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1 August 2017

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Brendan J Floyd

12

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Melkam Kebede

object named as

Melkam A Kebede

1

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Kevin Eliceiri

object named as

Kevin Eliceiri

15

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Nabil Seidah

object named as

Nabil G Seidah

16

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author name string

Angie T Oler

2

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1 August 2017

Trillian Gregg

3

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1 August 2017

Allison J Balloon

4

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1 August 2017

Adam Johnson

5

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1 August 2017

Kelly Mitok

6

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1 August 2017

Mary Rabaglia

7

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1 August 2017

Kathryn Schueler

8

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1 August 2017

Donald Stapleton

9

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1 August 2017

Candice Thorstenson

10

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1 August 2017

Lindsay Wrighton

11

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1 August 2017

Oliver Richards

13

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1 August 2017

Summer Raines

14

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1 August 2017

Christopher Rhodes

17

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1 August 2017

Mark P Keller

18

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1 August 2017

Joshua L Coon

19

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1 August 2017

Anjon Audhya

20

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1 August 2017

Alan D Attie

21

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1 August 2017

language of work or name

English

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publication date

26 August 2014

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Journal of Clinical Investigation

1 August 2017

published in

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1 August 2017

volume

124

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1 August 2017

issue

10

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1 August 2017

page(s)

4240-4256

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describes a project that uses

1 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4191024/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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6 July 2018

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SORCS1 contributes to the development of renal disease in rats and humans

6 July 2018

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The genetic variation of SORCS1 is associated with late-onset Alzheimer's disease in Chinese Han population.

6 July 2018

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PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance

6 July 2018

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PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A simple and rapid method for identifying and semi-quantifying peptide hormones in isolated pancreatic islets by direct-tissue matrix-assisted laser desorption ionization time-of-flight mass spectrometry

6 July 2018

1 reference

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Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.

6 July 2018

1 reference

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SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway

6 July 2018

1 reference

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Sortilins: new players in lipoprotein metabolism

6 July 2018

1 reference

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Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

6 July 2018

1 reference

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Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport

6 July 2018

1 reference

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Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex

6 July 2018

1 reference

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Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export

6 July 2018

1 reference

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From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

6 July 2018

1 reference

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Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass

6 July 2018

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An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells.

6 July 2018

1 reference

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Maturation of secretory granules.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose

6 July 2018

1 reference

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Genetic basis of beta-cell dysfunction in man.

6 July 2018

1 reference

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Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Sorting of lysosomal proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

VPS10P-domain receptors - regulators of neuronal viability and function.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Sortilin mediates the lysosomal targeting of cathepsins D and H

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

The luminal Vps10p domain of sortilin plays the predominant role in targeting to insulin-responsive Glut4-containing vesicles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Sortilin is essential for proNGF-induced neuronal cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Efficient trafficking of TGN38 from the endosome to the trans-Golgi network requires a free hydroxyl group at position 331 in the cytosolic domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

The proprotein convertases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Sorting and storage during secretory granule biogenesis: looking backward and looking forward

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

TGN38/41 recycles between the cell surface and the TGN: brefeldin A affects its rate of return to the TGN.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Isolation of yeast mutants defective in protein targeting to the vacuole

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Toxoplasma sortilin-like receptor regulates protein transport and is essential for apical secretory organelle biogenesis and host infection

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Human insulin vesicle dynamics during pulsatile secretion

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Release of the prohormone convertase PC1 from AtT-20 cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Are we overestimating the loss of beta cells in type 2 diabetes?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4191024

Formation of the insulin-containing secretory granule core occurs within immature beta-granules

28 October 2018

1 reference

12 December 2020

Functional and spatial segregation of secretory vesicle pools according to vesicle age

1 reference

12 December 2020

1 reference

12 December 2020

Sorting Ourselves Out: Seeking Consensus on Trafficking in the Beta-Cell

1 reference

12 December 2020

Differential Rates of Release of Newly Synthesized and of Stored Insulin from Pancreatic Islets*

1 reference

12 December 2020

Biogenesis of secretory granules in the trans-Golgi network of neuroendocrine and endocrine cells

1 reference

12 December 2020

Evidence that glucose "marks" beta cells resulting in preferential release of newly synthesized insulin

1 reference

12 December 2020

TGN38/41: a molecule on the move

1 reference

12 December 2020

Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI74072

1 reference

1 August 2017

1 reference

1 August 2017

1 reference