(Q34327238)

1 August 2017

title

Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization (English)

1 reference

1 August 2017

Ian B Spurr

1

1 reference

1 August 2017

Charles N Birts

2

1 reference

1 August 2017

Francesco Cuda

3

1 reference

1 August 2017

Stephen J Benkovic

4

1 reference

1 August 2017

Jeremy P Blaydes

5

1 reference

1 August 2017

Ali Tavassoli

6

1 reference

1 August 2017

publication date

4 July 2012

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1 August 2017

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1 August 2017

volume

13

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1 August 2017

issue

11

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1 August 2017

page(s)

1628-1634

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Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas

6 July 2018

1 reference

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Homodimeric enzymes as drug targets.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

CtBPs promote cell survival through the maintenance of mitotic fidelity.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

N-methylation of peptides: a new perspective in medicinal chemistry

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Split-intein mediated circular ligation used in the synthesis of cyclic peptide libraries in E. coli.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Genetically selected cyclic-peptide inhibitors of AICAR transformylase homodimerization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Inhibitors of de novo nucleotide biosynthesis as drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Production of cyclic peptides and proteins in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

The design of cancer chemotherapy: metabolic modulation and cellular de novo versus salvage metabolism.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

De novo purine nucleotide biosynthesis: cloning, sequencing and expression of a chicken PurH cDNA encoding 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Regulation of de novo and salvage pathways in chemotherapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

6 July 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200279

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200279

Stability and equilibria of promiscuous aggregates in high protein milieus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200279

Inhibition of HIV budding by a genetically selected cyclic peptide targeting the Gag-TSG101 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200279

Human AICAR transformylase: role of the 4-carboxamide of AICAR in binding and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200279

Antifolates targeting purine synthesis allow entry of tumor cells into S phase regardless of p53 function

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3517147

Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22764122

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Studies on the incorporation of precursors into purine and pyrimidine nucleotides via 'de novo' and 'salvage' pathways in normal lymphocytes and lymphoblastic cell-line cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22764122

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/CBIC.201200279

1 reference

1 August 2017

1 reference

1 August 2017

1 reference