(Q44586162)

English

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway

scientific article published in October 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 December 2017

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Ian Andrew Wilson

7

object named as

Ian A Wilson

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Europe PubMed Central

PubMed publication ID

4 December 2017

author name string

Joel Desharnais

1

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Europe PubMed Central

PubMed publication ID

4 December 2017

Inkyu Hwang

2

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Europe PubMed Central

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4 December 2017

Yan Zhang

3

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Ali Tavassoli

4

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Justin Baboval

5

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Europe PubMed Central

PubMed publication ID

4 December 2017

Stephen J Benkovic

6

1 reference

Europe PubMed Central

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4 December 2017

Dale L Boger

8

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

language of work or name

0 references

publication date

1 October 2003

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Europe PubMed Central

PubMed publication ID

4 December 2017

Bioorganic & Medicinal Chemistry

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Europe PubMed Central

PubMed publication ID

4 December 2017

11

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Europe PubMed Central

PubMed publication ID

4 December 2017

20

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Europe PubMed Central

PubMed publication ID

4 December 2017

4511-4521

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Europe PubMed Central

PubMed publication ID

4 December 2017

The transformylase enzymes of de novo purine biosynthesis

1 reference

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Inhibitors of de novo nucleotide biosynthesis as drugs

1 reference

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7 January 2021

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N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase

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7 January 2021

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Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogues

1 reference

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7 January 2021

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Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid

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Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents

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A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase

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Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate)

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7 January 2021

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Synthesis and biological activity of acyclic analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid

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7 January 2021

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Design and synthesis of inhibitors of folate-dependent enzymes as antitumor agents.

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7 January 2021

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Analogues of 10-deazaaminopterin and 5-alkyl-5,10-dideazaaminopterin with the 4-substituted 1-naphthoyl group in the place of 4-substituted benzoyl

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7 January 2021

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Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition

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7 January 2021

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Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA).

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7 January 2021

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A multisubstrate adduct inhibitor of AICAR transformylase

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7 January 2021

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The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3-d]pyrimidine based antifolates as antineoplastic and antiarthritic agents

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7 January 2021

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Synthesis and biological activity of 4-amino-7-oxo-substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid and 5,10-dideaza-5, 6,7,8-tetrahydrofolic acid

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7 January 2021

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Phase I study of AG2034, a targeted GARFT inhibitor, administered once every 3 weeks

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7 January 2021

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Synthesis and biological activity of 7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).

1 reference

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7 January 2021

based on heuristic

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10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase

1 reference

https://api.crossref.org/works/10.1016%2FS0968-0896%2803%2900458-9

7 January 2021

based on heuristic

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Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

1 reference

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7 January 2021

based on heuristic

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Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase

1 reference

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7 January 2021

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Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase

1 reference

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7 January 2021

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Multisubstrate analogue based on 5,8,10-trideazafolate

1 reference

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7 January 2021

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Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors.

1 reference

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7 January 2021

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Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase

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7 January 2021

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Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase

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7 January 2021

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10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway

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Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase

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Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid

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Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase

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Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol

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Induction of HL-60 leukemia cell differentiation by tetrahydrofolate inhibitors of de novo purine nucleotide biosynthesis

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1 reference

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7 January 2021

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Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR

1 reference

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Identifiers

10.1016/S0968-0896(03)00458-9

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

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