(Q34333585)

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Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells.

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13 February 2020

Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells (English)

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13 February 2020

apoptotic process

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phosphorylation

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13 February 2020

Nathalie Launay

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Nathalie Launay

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Patrick Vicart

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13 February 2020

Alain Lilienbaum

4

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13 February 2020

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14 September 2010

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13 February 2020

Journal of Biological Chemistry

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13 February 2020

285

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13 February 2020

48

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13 February 2020

37324-37332

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13 February 2020

describes a project that uses

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11 June 2022

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alphaB-crystallin: a novel p53-target gene required for p53-dependent apoptosis

1 reference

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Expression of alpha-crystallin in retinoblastoma

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Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism.

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AlphaB-crystallin: a novel marker of invasive basal-like and metaplastic breast carcinomas

1 reference

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6 July 2018

alphaB-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancer

1 reference

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Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma

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6 July 2018

Small heat shock protein alphaB-crystallin binds to p53 to sequester its translocation to mitochondria during hydrogen peroxide-induced apoptosis

1 reference

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6 July 2018

Association of alphaB-crystallin, a small heat shock protein, with actin: role in modulating actin filament dynamics in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988338

6 July 2018

Cell signaling pathways to alphaB-crystallin following stresses of the cytoskeleton

1 reference

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6 July 2018

Vincristine regulates the phosphorylation of the antiapoptotic protein HSP27 in breast cancer cells.

1 reference

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6 July 2018

Alpha-crystallin expression affects microtubule assembly and prevents their aggregation

1 reference

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6 July 2018

The distinctive role of small heat shock proteins in oncogenesis.

1 reference

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6 July 2018

AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer

1 reference

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6 July 2018

Is the small heat shock protein alphaB-crystallin an oncogene?

1 reference

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6 July 2018

Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy

1 reference

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6 July 2018

Promoting apoptosis as a strategy for cancer drug discovery

1 reference

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6 July 2018

Small heat shock proteins HSP27 and alphaB-crystallin: cytoprotective and oncogenic functions

1 reference

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6 July 2018

The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3.

1 reference

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6 July 2018

In search of the molecular mechanism by which small stress proteins counteract apoptosis during cellular differentiation

1 reference

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6 July 2018

Small heat shock protein alphaB-crystallin is part of cell cycle-dependent Golgi reorganization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988338

6 July 2018

alphaB-crystallin as a marker of lymph node involvement in breast carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988338

6 July 2018

p38 MAP kinase: a convergence point in cancer therapy

1 reference

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6 July 2018

Roles of molecular chaperones in protein misfolding diseases

1 reference

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6 July 2018

Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988338

6 July 2018

Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988338

6 July 2018

Nuclear staining for the small heat shock protein alphaB-crystallin colocalizes with splicing factor SC35.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988338

6 July 2018

The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2988338

6 July 2018

sHsp-phosphorylation: enzymes, signaling pathways and functional implications

1 reference

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Inhibition of Daxx-mediated apoptosis by heat shock protein 27

1 reference

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6 July 2018

alpha B-crystallin gene induction and phosphorylation by MKK6-activated p38. A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress response

1 reference

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Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation

1 reference

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1 reference

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Synthesis and accumulation of alphaB crystallin in C6 glioma cells is induced by agents that promote the disassembly of microtubules.

1 reference

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6 July 2018

The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124388

21 January 2018

Expression and prognostic significance of the alpha B-crystallin gene in human hepatocellular carcinoma.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124388

21 January 2018

alphaB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124388

21 January 2018

AlphaB-crystallin phosphorylated at Ser-59 is localized in centrosomes and midbodies during mitosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124388

21 January 2018

Phosphorylation of alphaB-crystallin and HSP27 is induced by similar stressors in HeLa cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124388

21 January 2018

Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124388

21 January 2018

alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124388

21 January 2018

Localization of phosphorylated alphaB-crystallin to heart mitochondria during ischemia-reperfusion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.124388

21 January 2018

Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20841355

12 December 2020

based on heuristic

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Identifiers

10.1074/JBC.M110.124388

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20841355%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20841355%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20841355%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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