(Q34334511)

1 August 2017

Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells (English)

1 reference

1 August 2017

Richard Callaghan

2

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Frances Platt

object named as

Frances M Platt

3

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author name string

Edward Norris-Cervetto

1

1 reference

1 August 2017

Raymond A Dwek

4

1 reference

1 August 2017

Terry D Butters

5

1 reference

1 August 2017

language of work or name

English

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publication date

19 July 2004

1 reference

Journal of Biological Chemistry

1 August 2017

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1 August 2017

279

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1 August 2017

40412-40418

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1 August 2017

39

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Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs

1 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Accumulation of glucosylceramides in multidrug-resistant cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Alteration of the daunorubicin-triggered sphingomyelin-ceramide pathway and apoptosis in MDR cells: influence of drug transport abnormalities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Chemotherapy by slowing glucosphingolipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Targeting ceramide metabolism--a strategy for overcoming drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Glucosylceramide synthase and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

The absence of functional glucosylceramide synthase does not sensitize melanoma cells for anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Differential effects of three inhibitors of glycosphingolipid biosynthesis on neuronal differentiation of embryonal carcinoma stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Modulation of cell-surface transferrin receptor by the imino sugar N-butyldeoxynojirimycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

High-performance liquid chromatography analysis of ganglioside carbohydrates at the picomole level after ceramide glycanase digestion and fluorescent labeling with 2-aminobenzamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Uncertain identity of doxorubicin-resistant MCF-7 cell lines expressing mutated p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Influence of genistein and daidzein on Brca1 protein levels in human breast cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

The effects of cyclosporin A, tamoxifen, and medroxyprogesterone acetate on the enhancement of adriamycin cytotoxicity in primary cultures of human breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Retroviral transfection of Madin-Darby canine kidney cells with human MDR1 results in a major increase in globotriaosylceramide and 10(5)- to 10(6)-fold increased cell sensitivity to verocytotoxin. Role of p-glycoprotein in glycolipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Ceramide glycosylation potentiates cellular multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

Improved Inhibitors of Glucosylceramide Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404466200

21 January 2018

Identifiers

DOI

10.1074/JBC.M404466200

1 reference

1 August 2017

1 reference