(Q34343350)

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PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 August 2017

PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. (English)

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Europe PubMed Central

PubMed publication ID

1 August 2017

Jacob M. Hooker

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25188794%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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F A Schroeder

1

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31 May 2020

C Wang

2

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31 May 2020

G C Van de Bittner

3

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31 May 2020

R Neelamegam

4

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31 May 2020

W R Takakura

5

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31 May 2020

A Karunakaran

6

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31 May 2020

H Y Wey

7

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31 May 2020

S A Reis

8

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31 May 2020

J Gale

9

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31 May 2020

Y L Zhang

10

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31 May 2020

E B Holson

11

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31 May 2020

S J Haggarty

12

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31 May 2020

publication date

19 September 2014

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1 August 2017

ACS Chemical Neuroscience

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31 May 2020

5

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31 May 2020

10

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31 May 2020

1055-1062

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31 May 2020

In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Antiproliferative and differentiating activities of a novel series of histone deacetylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.

1 reference

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6 July 2018

Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Clozapine, a fast-off-D2 antipsychotic

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6 July 2018

Therapeutic potential of isoform selective HDAC inhibitors for the treatment of schizophrenia

1 reference

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6 July 2018

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests

1 reference

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6 July 2018

SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition

1 reference

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6 July 2018

FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Class I HDAC imaging using [ (3)H]CI-994 autoradiography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Prefrontal cortical dysfunction after overexpression of histone deacetylase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Epigenetic mechanisms in mood disorders: targeting neuroplasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

The potential of HDAC inhibitors as cognitive enhancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

An epigenetic blockade of cognitive functions in the neurodegenerating brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Targeting the correct HDAC(s) to treat cognitive disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Histone deacetylase inhibitor, MS-275, exhibits poor brain penetration: PK studies of [C]MS-275 using Positron Emission Tomography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Antidepressant actions of histone deacetylase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

HDAC2 negatively regulates memory formation and synaptic plasticity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: analysis of the National Brain Databank microarray collection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Dose translation from animal to human studies revisited

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4198064

6 July 2018

Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars

1 reference

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6 July 2018

Distribution of histone deacetylases 1-11 in the rat brain

1 reference

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A comparison between Dark Agouti and Sprague-Dawley rats in their behaviour on the elevated plus-maze, open-field apparatus and activity meters, and their response to diazepam

1 reference

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6 July 2018

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

1 reference

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Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine

1 reference

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Effects of valproate on hyponeophagia in rats: competitive antagonism with picrotoxin and non-competitive antagonism with RO 15-1788.

1 reference

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6 July 2018

Chemoproteomics reveals time-dependent binding of histone deacetylase inhibitors to endogenous repressor complexes.

1 reference

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27 October 2018

Valproate induces DNA demethylation in nuclear extracts from adult mouse brain

1 reference

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27 October 2018

Chronic microinjection of valproic acid into the nucleus accumbens attenuates amphetamine-induced locomotor activity

1 reference

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27 October 2018

Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system

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27 October 2018

Identifiers

10.1021/CN500162J

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Europe PubMed Central

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31 May 2020

PMC publication ID

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31 May 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25188794%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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