(Q34347238)

1 August 2017

title

Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity (English)

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3

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8

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4

Juan J Marugan

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1 August 2017

2

Seameen J Dehdashti

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1 August 2017

Aaron B Krueger

1

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1 August 2017

Marc Ferrer

5

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1 August 2017

Xueni Li

6

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1 August 2017

Heide L Ford

7

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1 August 2017

Rui Zhao

9

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1 August 2017

publication date

20 July 2012

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Journal of Biomolecular Screening

1 August 2017

published in

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1 August 2017

volume

18

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1 August 2017

issue

1

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1 August 2017

page(s)

85-96

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Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties

1 August 2017

cites work

1 reference

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The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins

6 July 2018

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Regulatory cascades of protein phosphatases: implications for cancer treatment

6 July 2018

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The Eyes Absent phosphatase-transactivator proteins promote proliferation, transformation, migration, and invasion of tumor cells

6 July 2018

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Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1

6 July 2018

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Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on homeoprotein Six1.

6 July 2018

1 reference

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Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling

6 July 2018

1 reference

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Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

6 July 2018

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Regulation of the innate immune response by threonine-phosphatase of Eyes absent

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

The six family of homeobox genes in development and cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Development and optimization of high-throughput in vitro protein phosphatase screening assays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Protein tyrosine phosphatases: from genes, to function, to disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

A comparative study of Eya1 and Eya4 protein function and its implication in branchio-oto-renal syndrome and DFNA10

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Eyes absent represents a class of protein tyrosine phosphatases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

A gene-expression signature as a predictor of survival in breast cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3893891

The transcription factor Eyes absent is a protein tyrosine phosphatase

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1177%2F1087057112453936

Radiation oncology: a century of achievements.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1177%2F1087057112453936

Structure-based virtual screening approach to the discovery of novel inhibitors of eyes absent 2 phosphatase with various metal chelating moieties.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1177%2F1087057112453936

21 January 2018

Identifiers

DOI

10.1177/1087057112453936

1 reference

1 August 2017

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1 August 2017

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