(Q34347694)

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A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

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Europe PubMed Central

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2 March 2020

A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors (English)

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2 March 2020

Human Induced Pluripotent Stem Cells

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inferred from title

2

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2 March 2020

Inmaculada Moreno-Gimeno

3

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2 March 2020

Gabriele Saretzki

8

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2 March 2020

10

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2 March 2020

14

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2 March 2020

16

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2 March 2020

author name string

K Tilgner

1

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2 March 2020

J Y Al-Aama

4

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2 March 2020

D Burks

5

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2 March 2020

S Yung

6

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2 March 2020

C Singhapol

7

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2 March 2020

J Evans

9

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2 March 2020

A Gennery

11

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2 March 2020

S Przyborski

12

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2 March 2020

M Stojkovic

13

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2 March 2020

P Jeggo

15

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2 March 2020

publication date

31 May 2013

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2 March 2020

Cell Death & Differentiation

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2 March 2020

20

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2 March 2020

8

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2 March 2020

1089-1100

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2 March 2020

https://scigraph.springernature.com/pub.10.1038/cdd.2013.44

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SCL/TAL1 regulates hematopoietic specification from human embryonic stem cells

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6 July 2018

Overcoming reprogramming resistance of Fanconi anemia cells

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6 July 2018

Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells.

1 reference

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6 July 2018

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

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6 July 2018

Large-scale transcriptional profiling and functional assays reveal important roles for Rho-GTPase signalling and SCL during haematopoietic differentiation of human embryonic stem cells

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6 July 2018

Requirement for DNA ligase IV during embryonic neuronal development

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6 July 2018

Human induced pluripotent cells resemble embryonic stem cells demonstrating enhanced levels of DNA repair and efficacy of nonhomologous end-joining

1 reference

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6 July 2018

Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2.

1 reference

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6 July 2018

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

1 reference

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6 July 2018

Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Regulation of DNA strand exchange in homologous recombination

1 reference

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6 July 2018

Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

The DNA-damage response in human biology and disease

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6 July 2018

Mechanisms of double-strand break repair in somatic mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

DNA repair is limiting for haematopoietic stem cells during ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures

1 reference

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6 July 2018

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Derivation of human embryonic stem cells from day-8 blastocysts recovered after three-step in vitro culture.

1 reference

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6 July 2018

An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome

1 reference

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6 July 2018

Mechanism and regulation of human non-homologous DNA end-joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

1 reference

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6 July 2018

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

1 reference

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6 July 2018

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

1 reference

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6 July 2018

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

1 reference

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6 July 2018

Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

1 reference

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6 July 2018

DNA breakage and repair

1 reference

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6 July 2018

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

6 July 2018

A patient with mutations in DNA Ligase IV: clinical features and overlap with Nijmegen breakage syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2013.44

21 January 2018

Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2013.44

21 January 2018

Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2013.44

21 January 2018

Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2013.44

21 January 2018

Analysis of DNA double-strand break (DSB) repair in mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3705601

27 October 2018

A backup DNA repair pathway moves to the forefront

1 reference

https://pubmed.ncbi.nlm.nih.gov/23722522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23722522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23722522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High resolution array-CGH characterization of human stem cells using a stem cell focused microarray

1 reference

https://pubmed.ncbi.nlm.nih.gov/23722522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recurrent copy number variations in human induced pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23722522

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligase IV syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2013.44

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CDD.2013.44

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23722522%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23722522%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23722522%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

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