(Q34352138)

1 August 2017

title

Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones (English)

1 reference

1 August 2017

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6

Hilal A Lashuel

1 reference

1 August 2017

Marie-Pierre Hinault

1

1 reference

1 August 2017

America Farina Henriquez Cuendet

2

1 reference

1 August 2017

Rayees U H Mattoo

3

1 reference

1 August 2017

Mounir Mensi

4

1 reference

1 August 2017

Giovanni Dietler

5

1 reference

1 August 2017

Pierre Goloubinoff

7

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1 August 2017

language of work or name

English

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publication date

16 September 2010

1 reference

Journal of Biological Chemistry

1 August 2017

published in

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1 August 2017

volume

285

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1 August 2017

issue

49

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1 August 2017

page(s)

38173-38182

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The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

1 August 2017

cites work

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A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation

6 July 2018

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Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity

6 July 2018

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6 July 2018

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6 July 2018

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Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones

6 July 2018

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Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

6 July 2018

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Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

6 July 2018

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6 July 2018

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Physiological and pathological properties of alpha-synuclein

6 July 2018

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Chaperones and proteases: cellular fold-controlling factors of proteins in neurodegenerative diseases and aging.

6 July 2018

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Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling

6 July 2018

1 reference

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Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells

6 July 2018

1 reference

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Progressive disruption of cellular protein folding in models of polyglutamine diseases.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

The Escherichia coli DjlA and CbpA proteins can substitute for DnaJ in DnaK-mediated protein disaggregation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

cis-Effect of DnaJ on DnaK in ternary complexes with chimeric DnaK/DnaJ-binding peptides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Its substrate specificity characterizes the DnaJ co-chaperone as a scanning factor for the DnaK chaperone.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Principles that govern the folding of protein chains

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

The heat-shock protein ClpB in Escherichia coli is a protein-activated ATPase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease.

6 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Active solubilization and refolding of stable protein aggregates by cooperative unfolding action of individual hsp70 chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Size-dependent disaggregation of stable protein aggregates by the DnaK chaperone machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Protein homeostasis and aging: The importance of exquisite quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

DnaK/DnaJ/GrpE of Hsp70 system have differing effects on alpha-synuclein fibrillation involved in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Molecular basis for regulation of the heat shock transcription factor sigma32 by the DnaK and DnaJ chaperones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Meta-analysis of heat- and chemically upregulated chaperone genes in plant and human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Structural properties of pore-forming oligomers of alpha-synuclein

21 January 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992251

27 October 2018

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

Heat Shock Protein 70 Inhibits α-Synuclein Fibril Formation via Interactions with Diverse Intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.127753

alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20847048

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The small heat-shock protein IbpB from Escherichia coli stabilizes stress-denatured proteins for subsequent refolding by a multichaperone network

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20847048

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20847048

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.127753

1 reference

1 August 2017

1 reference

1 August 2017

1 reference