(Q34353299)

1 August 2017

title

Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease (English)

1 reference

1 August 2017

8

Sina Bavari

1 reference

1 August 2017

5

Peter Wipf

1 reference

1 August 2017

Jonathan E Nuss

1

1 reference

1 August 2017

Yuxiang Dong

2

1 reference

1 August 2017

Laura M Wanner

3

1 reference

1 August 2017

Gordon Ruthel

4

1 reference

1 August 2017

Rick Gussio

6

1 reference

1 August 2017

Jonathan L Vennerstrom

7

1 reference

1 August 2017

James C Burnett

9

1 reference

1 August 2017

publication date

1 October 2010

1 reference

ACS Medicinal Chemistry Letters

1 August 2017

published in

1 reference

1 August 2017

volume

1

1 reference

1 August 2017

issue

7

1 reference

1 August 2017

page(s)

301-305

1 reference

Investigations into small molecule non-peptidic inhibitors of the botulinum neurotoxins

1 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

The strange case of the botulinum neurotoxin: using chemistry and biology to modulate the most deadly poison

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Strategies to design inhibitors of Clostridium botulinum neurotoxins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Analyzing a bioterror attack on the food supply: the case of botulinum toxin in milk

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Synthesis of analogues of Congo red and evaluation of their anti-prion activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Getting muscles moving again after botulinum toxin: novel therapeutic challenges

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Fluorigenic substrates for the protease activities of botulinum neurotoxins, serotypes A, B, and F.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Botulinum Toxin as a Biological Weapon: Medical and Public Health Management

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Proteolysis of synthetic peptides by type A botulinum neurotoxin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

High-throughput assays for botulinum neurotoxin proteolytic activity: serotypes A, B, D, and F.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992458

Endoproteinase activity of type A botulinum neurotoxin: substrate requirements and activation by serum albumin

27 October 2018

1 reference

12 December 2020

Type A botulinum neurotoxin proteolytic activity: development of competitive inhibitors and implications for substrate specificity at the S1' binding subsite

1 reference

12 December 2020

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease

1 reference

12 December 2020

Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease

1 reference

12 December 2020

Identifiers

DOI

10.1021/ML100056V

1 reference

1 August 2017

1 reference

1 August 2017

1 reference