(Q41772843)

English

4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria

scientific article published on June 2008

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scholarly article

1 reference

Europe PubMed Central

9 October 2017

4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria (English)

1 reference

Europe PubMed Central

9 October 2017

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Leah B Casabianca

5

object named as

Leah B Casabianca

1 reference

Europe PubMed Central

9 October 2017

author name string

Jayakumar K Natarajan

1

1 reference

Europe PubMed Central

9 October 2017

John N Alumasa

2

1 reference

Europe PubMed Central

9 October 2017

Kimberly Yearick

3

1 reference

Europe PubMed Central

9 October 2017

Kekeli A Ekoue-Kovi

4

1 reference

Europe PubMed Central

9 October 2017

Angel C de Dios

6

1 reference

Europe PubMed Central

9 October 2017

Christian Wolf

7

1 reference

Europe PubMed Central

9 October 2017

Paul D Roepe

8

1 reference

Europe PubMed Central

9 October 2017

language of work or name

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publication date

1 June 2008

1 reference

Europe PubMed Central

9 October 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

9 October 2017

51

1 reference

Europe PubMed Central

9 October 2017

3466-3479

1 reference

Europe PubMed Central

9 October 2017

12

1 reference

Europe PubMed Central

9 October 2017

Malaria-infected mice are cured by a single dose of novel artemisinin derivatives

1 reference

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Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening

1 reference

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6 June 2018

Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance

1 reference

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6 June 2018

Structure-function correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery

1 reference

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6 June 2018

Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum

1 reference

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6 June 2018

Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria

1 reference

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6 June 2018

Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.

1 reference

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6 June 2018

Probing the role of the covalent linkage of ferrocene into a chloroquine template

1 reference

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6 June 2018

Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum.

1 reference

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6 June 2018

Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol

1 reference

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Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity

1 reference

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6 June 2018

Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.

1 reference

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6 June 2018

Design and synthesis of new antimalarial agents from 4-aminoquinoline

1 reference

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6 June 2018

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities.

1 reference

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Structure of the amodiaquine-FPIX mu oxo dimer solution complex at atomic resolution

1 reference

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6 June 2018

Identification of an antimalarial synthetic trioxolane drug development candidate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637136

6 June 2018

Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637136

6 June 2018

The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637136

6 June 2018

Parallel synthesis and antimalarial screening of a 4-aminoquinoline library

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637136

6 June 2018

Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.

1 reference

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6 June 2018

Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637136

6 June 2018

Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637136

6 June 2018

Effects of solvent composition and ionic strength on the interaction of quinoline antimalarials with ferriprotoporphyrin IX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2637136

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Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery

1 reference

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6 June 2018

Carbon isosteres of the 4-aminopyridine substructure of chloroquine: effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth

1 reference

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Synthesis of aza mono, bi and tricyclic compounds. Evaluation of their anti MDR activity

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Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum

1 reference

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6 June 2018

Chloroquine resistance in the malarial parasite, Plasmodium falciparum

1 reference

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Solution structures of antimalarial drug-heme complexes

1 reference

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Preparation and antimalarial activities of "trioxaquines", new modular molecules with a trioxane skeleton linked to a 4-aminoquinoline

1 reference

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Modulation of human mammary cell sensitivity to paclitaxel by new quinoline sulfonamides

1 reference

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Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines

1 reference

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6 June 2018

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

1 reference

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Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth

1 reference

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Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines.

1 reference

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1 reference

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Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX.

1 reference

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6 June 2018

4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

1 reference

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6 June 2018

Temperature dependence of the acid dissociation constants of chloroquine

1 reference

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Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.

1 reference

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Synchronization of Plasmodium falciparum Erythrocytic Stages in Culture

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The synthesis of some 7-chloro-4-(3-alkylamino-propylamino) quinolines.

1 reference

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Synthetic antimalarials; the preparation of certain 4-aminoquinolines.

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The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites

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Malaria: a protective paradox.

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Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates.

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Synthesis and antimalarial activity of trioxaquine derivatives

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Synthesis and antimalarial activity of a new series of trioxaquines

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Some dialkylaminoalkyl sulfides and ethers derived from quinoline and acridine heterocycles

1 reference

https://pubmed.ncbi.nlm.nih.gov/18512900

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based on heuristic

inferred from PubMed ID database lookup

Some 7-substituted 4-aminoquinoline derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/18512900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative study of the inhibition of metallo-beta-lactamases (IMP-1 and VIM-2) by thiol compounds that contain a hydrophobic group

1 reference

https://pubmed.ncbi.nlm.nih.gov/18512900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides

1 reference

https://pubmed.ncbi.nlm.nih.gov/18512900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18512900

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1021/JM701478A

1 reference

Europe PubMed Central

9 October 2017

1 reference

Europe PubMed Central

9 October 2017

1 reference

Europe PubMed Central

9 October 2017

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