(Q34355248)

1 August 2017

title

Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets (English)

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1 August 2017

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Kyle W Sloop

1

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1 August 2017

Francis S Willard

2

1 reference

1 August 2017

Martin B Brenner

3

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1 August 2017

James Ficorilli

4

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1 August 2017

Kathleen Valasek

5

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1 August 2017

Aaron D Showalter

6

1 reference

1 August 2017

Thomas B Farb

7

1 reference

1 August 2017

Julia X C Cao

8

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1 August 2017

Amy L Cox

9

1 reference

1 August 2017

M Dodson Michael

10

1 reference

1 August 2017

Sonia Maria Gutierrez Sanfeliciano

11

1 reference

1 August 2017

Mark J Tebbe

12

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1 August 2017

Michael J Coghlan

13

1 reference

1 August 2017

language of work or name

English

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publication date

7 September 2010

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1 August 2017

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1 August 2017

volume

59

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1 August 2017

issue

12

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1 August 2017

page(s)

3099-3107

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

1 August 2017

copyright license

start time

28 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

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Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

6 July 2018

1 reference

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Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective.

6 July 2018

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Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study

6 July 2018

1 reference

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Incretin-based therapies in type 2 diabetes mellitus

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Structural diversity of G protein-coupled receptors and significance for drug discovery

6 July 2018

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Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology.

6 July 2018

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Synthesis and antidiabetic activity of 3,6,7-trisubstituted-2-(1H-imidazol-2-ylsulfanyl)quinoxalines and quinoxalin-2-yl isothioureas

6 July 2018

1 reference

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Small-molecule agonists for the glucagon-like peptide 1 receptor

6 July 2018

1 reference

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A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice

6 July 2018

1 reference

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Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells

6 July 2018

1 reference

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Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism.

6 July 2018

1 reference

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Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

6 July 2018

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A buffer temperature controlled perifusion system to study temperature dependence and kinetics of insulin secretion in MIN6 pseudoislets

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

6 July 2018

1 reference

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The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Glucose-induced insulin secretion is potentiated by a new imidazoline compound

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Receptors for VIP, PACAP, secretin, GRF, glucagon, GLP-1, and other members of their new family of G protein-linked receptors: structure-function relationship with special reference to the human VIP-1 receptor

6 July 2018

1 reference

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Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized clinical trials

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Molecular modeling of the three-dimensional structure of GLP-1R and its interactions with several agonists

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Allosteric ligands for the corticotropin releasing factor type 1 receptor modulate conformational states involved in receptor activation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Allosteric Modulation of G Protein–Coupled Receptors

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Hantzsch synthesis of pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridines: partial agonists of the calcitonin receptor.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992771

Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20823098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Glucose-dependent action of glucagon-like peptide-1(7-37) in vivo during short- or long-term administration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20823098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20823098

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2337/DB10-0689

1 reference

1 August 2017

0 references

1 reference

1 August 2017

1 reference