(Q34360881)

1 August 2017

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title

siRNA therapeutics: big potential from small RNAs (English)

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1 August 2017

Ryther RC

1

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1 August 2017

Flynt AS

series ordinal

2

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1 August 2017

Phillips JA 3rd

series ordinal

3

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1 August 2017

Patton JG

series ordinal

4

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1 August 2017

publication date

1 January 2005

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1 August 2017

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1 August 2017

volume

12

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1 August 2017

issue

1

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1 August 2017

page(s)

5-11

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302356

1 August 2017

exact match

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cites work

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

siRNAs can function as miRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

RNA interference is mediated by 21- and 22-nucleotide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Role for a bidentate ribonuclease in the initiation step of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

How cells respond to interferons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Activation of the interferon system by short-interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Allele-specific silencing of dominant disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Pre-mRNA splicing and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Exon-specific RNAi: a tool for dissecting the functional relevance of alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

GH1 splicing is regulated by multiple enhancers whose mutation produces a dominant-negative GH isoform that can be degraded by allele-specific small interfering RNA (siRNA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Therapeutic gene silencing in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Caspase 8 small interfering RNA prevents acute liver failure in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Specificity of short interfering RNA determined through gene expression signatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Dissecting HIV-1 through RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

RNA interference--a new weapon against HIV and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Nucleic acid-based immune system: the antiviral potential of mammalian RNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Human immunodeficiency virus type 1 escape from RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Short interfering RNA confers intracellular antiviral immunity in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Molecular mechanism of RNA silencing suppression mediated by p19 protein of tombusviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

siRNA function in RNAi: a chemical modification analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Tolerance for mutations and chemical modifications in a siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

RNA interference in adult mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Electroporation and RNA interference in the rodent retina in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Lack of efficacy of 'naked' small interfering RNA applied directly to rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Modulation of HIV-1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Inhibition of retroviral pathogenesis by RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Promoter choice affects the potency of HIV-1 specific RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Short interfering RNA-directed inhibition of hepatitis B virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Inhibition of hepatitis B virus in mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Interference of hepatitis C virus RNA replication by short interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Inhibition of hepatitis C virus protein expression by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Rotavirus gene silencing by small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

CD46 is a cellular receptor for group B adenoviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Inhibition of gammaherpesvirus replication by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Inducible shRNA expression for application in a prostate cancer mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

Toward therapy for DYT1 dystonia: allele-specific silencing of mutant TorsinA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

7 January 2021

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

7 January 2021

Two isoforms of sarco/endoplasmic reticulum calcium ATPase (SERCA) are essential in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

7 January 2021

RNA interference targeting Fas protects mice from fulminant hepatitis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

7 January 2021

RNA interference: a promising approach to antiviral therapy?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

7 January 2021

Gene silencing by systemic delivery of synthetic siRNAs in adult mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

7 January 2021

siRNA-directed inhibition of HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

7 January 2021

Choosing CCR5 or Rev siRNA in HIV-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

7 January 2021

Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302356

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302356

1 reference

Dimensions Publication ID

1 August 2017

1014048334

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1 reference