(Q34364484)

1 August 2017

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title

Regulation of the DNA methylation machinery and its role in cellular transformation (English)

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1 August 2017

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Szyf M

1

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1 August 2017

Detich N

series ordinal

2

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1 August 2017

publication date

1 January 2001

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Progress in Molecular Biology and Translational Science

1 August 2017

published in

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1 August 2017

volume

69

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1 August 2017

page(s)

47-79

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DNA methylation properties: consequences for pharmacology

1 August 2017

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CpG methylation, chromatin structure and gene silencing-a three-way connection

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7 January 2021

X inactivation, differentiation, and DNA methylation

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7 January 2021

Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation

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7 January 2021

Methylation of CpG sites of two X-linked genes coincides with X-inactivation in the female mouse embryo but not in the germ line

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7 January 2021

X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse

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7 January 2021

X Inactivation in the Mouse Embryo Deficient for Dnmt1: Distinct Effect of Hypomethylation on Imprinted and Random X Inactivation

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7 January 2021

Developmental consequences of imprinting of parental chromosomes by DNA methylation.

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7 January 2021

Parental imprinting of the H19 and Igf2 genes in the mouse

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7 January 2021

Cytosine methylation and mammalian development

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7 January 2021

DNA methylation represses transcription in vivo.

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7 January 2021

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

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7 January 2021

Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region

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7 January 2021

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

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7 January 2021

CpG methylation inhibits binding of several sequence-specific DNA-binding proteins from pea, wheat, soybean and cauliflower

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7 January 2021

The c-fos cAMP-response element: regulation of gene expression by a beta 2-adrenergic agonist, serum and DNA methylation

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7 January 2021

Transcriptional control: imprinting insulation

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7 January 2021

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

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7 January 2021

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

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7 January 2021

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

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7 January 2021

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Cytosine methylation does not affect binding of transcription factor Sp1

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7 January 2021

Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

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7 January 2021

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

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7 January 2021

A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins

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7 January 2021

Identification and characterization of a family of mammalian methyl-CpG binding proteins

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Active repression of methylated genes by the chromosomal protein MBD1

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2.

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms

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7 January 2021

DNA methylation and chromosome instability in breast cancer cell lines

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7 January 2021

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

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7 January 2021

The DNA (cytosine-5) methyltransferases

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7 January 2021

Cloning of a mammalian DNA methyltransferase

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7 January 2021

Genomic structure of the human DNA methyltransferase gene

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7 January 2021

Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated dna.

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7 January 2021

Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation

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7 January 2021

Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure

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7 January 2021

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

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7 January 2021

Substrate and sequence specificity of a eukaryotic DNA methylase

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7 January 2021

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

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7 January 2021

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

DNA methylation in early development

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Variations in DNA methylation during mouse cell differentiation in vivo and in vitro

1 reference

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7 January 2021

The amazing demethylase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Modulation of DNA binding protein affinity directly affects target site demethylation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Mechanisms of DNA demethylation in chicken embryos. Purification and properties of a 5-methylcytosine-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Mechanism of active DNA demethylation during embryonic development and cellular differentiation in vertebrates

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

The RNA moiety of chick embryo 5-methylcytosine- DNA glycosylase targets DNA demethylation

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

A re-investigation of the ribonuclease sensitivity of a DNA demethylation reaction in chicken embryo and G8 mouse myoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

A CpG-rich RNA and an RNA helicase tightly associated with the DNA demethylation complex are present mainly in dividing chick embryo cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

DNA demethylation in vitro: involvement of RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Active demethylation of the paternal genome in the mouse zygote

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Ras induces a general DNA demethylation activity in mouse embryonal P19 cells

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7 January 2021

DNA demethylase is a processive enzyme

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7 January 2021

A mammalian protein with specific demethylase activity for mCpG DNA.

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7 January 2021

How does DNA methyltransferase cause oncogenic transformation?

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7 January 2021

The DNA methylation machinery as a therapeutic target

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7 January 2021

Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene

1 reference

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7 January 2021

Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway

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7 January 2021

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.

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7 January 2021

The regulation of AP-1 activity by mitogen-activated protein kinases

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7 January 2021

The Ras-JNK pathway is involved in shear-induced gene expression

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7 January 2021

Regulation of DNA methylation by the Ras signaling pathway

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7 January 2021

Increased cytosine DNA-methyltransferase activity during colon cancer progression

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7 January 2021

Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Role of DNA 5-methylcytosine transferase in cell transformation by fos

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7 January 2021

Association of K-ras mutations with p16 methylation in human colon cancer

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7 January 2021

DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen

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https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Downregulation of DNA (cytosine-5-)methyltransferase is a late event in NGF-induced PC12 cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Nerve growth factor induced differentiation of neuronal cells requires gene methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Stabilization of beta-catenin by genetic defects in melanoma cell lines

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7 January 2021

TCF/LEF factor earn their wings

1 reference

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7 January 2021

Identification of c-MYC as a target of the APC pathway

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7 January 2021

Suppression of intestinal neoplasia by DNA hypomethylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Concurrent replication and methylation at mammalian origins of replication

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Identification of initiation sites for DNA replication in the human dnmt1 (DNA-methyltransferase) locus

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

The retinoblastoma gene product regulates Sp1-mediated transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Retinoblastoma protein associates with SP1 and activates the hamster dihydrofolate reductase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Differential role for Sp1/Sp3 transcription factors in the regulation of the promoter activity of multiple cyclin-dependent kinase inhibitor genes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Inhibition of DNA methyltransferase inhibits DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

DNA hypomethylation in Morris hepatomas

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Hypomethylation of ras oncogenes in primary human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Alterations in DNA methylation in human colon neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Hypomethylation of CpG sites and c-myc gene overexpression in hepatocellular carcinomas, but not hyperplastic nodules, induced by a choline-deficient L-amino acid-defined diet in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Global DNA hypomethylation in breast carcinoma: correlation with prognostic factors and tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Hypermethylation at a chromosome 17 "hot spot" is a common event in ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Abnormal methylation of estrogen receptor gene and reduced estrogen receptor RNA levels in human endometrial carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Different methylation of oestrogen receptor DNA in human breast carcinomas with and without oestrogen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Human breast and colon cancers exhibit alterations of DNA methylation patterns at several DNA segments on chromosomes 11p and 17p

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

p300 collaborates with Sp1 and Sp3 in p21(waf1/cip1) promoter activation induced by histone deacetylase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Aging, DNA methylation and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

CpG island methylator phenotypes in aging and cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

CpG-island methylation in aging and cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

CpG methylation is maintained in human cancer cells lacking DNMT1.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Mutations truncating the EP300 acetylase in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

DNA methylation: a secondary event in globin gene switching?

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

cis modification of the steroid 21-hydroxylase gene prevents its expression in the Y1 mouse adrenocortical tumor cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Parental imprinting of genes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

Promoter-region hypermethylation and gene silencing in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6603%2801%2969044-5

7 January 2021

10.1016/S0079-6603(01)69044-5

Identifiers

DOI

1 reference

1 August 2017

1 reference