(Q34369172)

1 August 2017

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title

Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors (English)

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1 August 2017

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Komarova EA

1

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PubMed ID

11556286

1 August 2017

Gudkov AV

series ordinal

2

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PubMed ID

11556286

1 August 2017

language of work or name

English

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publication date

1 September 2001

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1 August 2017

Biochemical Pharmacology

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1 August 2017

62

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1 August 2017

657-667

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1 August 2017

6

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Germline p53 mutations and heritable cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Gamma-ray-induced cell killing and chromosome abnormalities in the bone marrow of p53-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

P53 deficiency produces fewer regenerating spermatogenic tubules after irradiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 deficiency sensitizes clonogenic cells to irradiation in the large but not the small intestine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Molecular basis of anthracycline-induced cardiotoxicity and its prevention

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Prediction of normal tissue damage induced by cancer chemotherapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Cisplatin-associated neurotoxicity: can it be prevented?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Radionuclide injury to the lung

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Effects of gamma irradiation on dermal equivalents in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 is required for radiation-induced apoptosis in mouse thymocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Thymocyte apoptosis induced by p53-dependent and independent pathways.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Could p53 be a target for therapeutic suppression?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

The treatment of malignancy by hyperthermia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Hyperthermia and liposomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Heat shock induces transient p53-dependent cell cycle arrest at G1/S.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Heat shock-induced necrosis and apoptosis in osteoblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Heat-induced G1 arrest is dependent on p53 function but not on RB dephosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Accumulation of mutant p53 and hsp72 by heat treatment, and their association in a human glioblastoma cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Heat-induced apoptosis and p53 in cultured mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Susceptibility of AML cells to in vitro apoptosis correlates with heat shock protein 70 (hsp 70) expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

The dependence of p53 on the radiation enhancement of thermosensitivity at different let.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

A comparison of p53 and p16 expression in human tumor cells treated with hyperthermia or ionizing radiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Tumor suppressor p53 gene forms multiple isoforms: evidence for single locus origin and cytoplasmic complex formation with heat shock proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Geldanamycin prevents nuclear translocation of mutant p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

HSP70 binding sites in the tumor suppressor protein p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Binding between wild-type p53 and hsp72 accumulated after UV and gamma-ray irradiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Induction of heat shock protein 70 protects thymocytes against radiation-induced apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Height and breast cancer risk--the bias of self-reported versus measured results. Comments on height and breast cancer risk, Tavani et al., Eur J Cancer 1998, 34, 543-547.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Teratogen update: gestational effects of maternal hyperthermia due to febrile illnesses and resultant patterns of defects in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

High-frequency developmental abnormalities in p53-deficient mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53-dependent apoptosis suppresses radiation-induced teratogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Tumor suppressors: a developing role for p53?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Improved therapeutic response by distinct timing of multiple heat treatments during interstitial radiation in the Dunning R3327 prostate tumor model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration (fever-like) whole body hyperthermia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Therapeutic efficacy and apoptosis and necrosis kinetics of doxorubicin compared with cisplatin, combined with whole-body hyperthermia in a rat mammary adenocarcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Apoptosis and p53 protein expression increase in the process of burn wound healing in guinea-pig skin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Apoptosis of hair follicle cells in the second-degree burn wound unders hypernatremic conditions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Cutaneous burn increases apoptosis in the gut epithelium of mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Major burn trauma in rats promotes cardiac and gastrointestinal apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Chinonin, a novel drug against cardiomyocyte apoptosis induced by hypoxia and reoxygenation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Redox regulation of p53 during hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Cell transforming genes and tumor progression: in vivo unified secondary phenotypic cell changes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 induction is associated with neuronal damage in the central nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Induction of tumor suppressor p53 and DNA fragmentation in organotypic hippocampal cultures following excitotoxin treatment.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

[Neuroprotection by neurotrophic factors in apoptosis]

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Involvement of p53 in DNA strand break-induced apoptosis in postmitotic CNS neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Roles of p53, c-Myc, Bcl-2, Bax and caspases in serum deprivation-induced neuronal apoptosis: a possible neuroprotective mechanism of basic fibroblast growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Apoptosis and schizophrenia: is the tumour suppressor gene, p53, a candidate susceptibility gene?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 inhibits hypoxia-inducible factor-stimulated transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

The differential expression of apoptosis factors in the alveolar epithelium is redox sensitive and requires NF-kappaB (RelA)-selective targeting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Expression of hypoxia-inducible factor 1: mechanisms and consequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Cellular oxygen sensing by mitochondria: old questions, new insight

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Increase in p53 protein expression following cortical infarction in the spontaneously hypertensive rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Activation of p53 and its target genes p21(WAF1/Cip1) and PAG608/Wig-1 in ischemic preconditioning.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Apoptosis and protein expression after focal cerebral ischemia in rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

ZFM1/SF1 mRNA in rat and gerbil brain after global ischaemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Attenuation of p53 expression protects against focal ischemic damage in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Apoptosis and expression of p53 response proteins and cyclin D1 after cortical impact in rat brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

The tumor-suppressor gene, p53, is induced in injured brain regions following experimental traumatic brain injury.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Changes in apoptosis-related protein (p53, Bax, Bcl-2 and Fos) expression with DNA fragmentation in the central nervous system in rats after closed head injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Postinjury magnesium treatment attenuates traumatic brain injury-induced cortical induction of p53 mRNA in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

p53 Induces myocyte apoptosis via the activation of the renin-angiotensin system.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

The bcl-2 gene product prevents programmed cell death of ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Pacing-induced heart failure in dogs enhances the expression of p53 and p53-dependent genes in ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Increased p53 protein expression in human failing myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Cardiomyocyte apoptosis with enhanced expression of P53 and Bax in right ventricle after pulmonary arterial banding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

ONYX-015: clinical data are encouraging

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

MDM2 oncogene as a novel target for human cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Pharmacological rescue of mutant p53 conformation and function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Caspase inhibitors are functionally neuroprotective against oxygen glucose deprivation induced CA1 death in rat organotypic hippocampal slices

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

In vivo myocardial infarct size reduction by a caspase inhibitor administered after the onset of ischemia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Caspase inhibitors reduce neuronal injury after focal but not global cerebral ischemia in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

Hyperthermia and radiation therapy of local-regional recurrent breast cancer: prognostic factors for response and local control of diffuse or nodular tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2801%2900733-X

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(01)00733-X

1 reference

1 August 2017

1 reference

PubMed ID

11556286