(Q34370111)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24023004%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them (English)

1 reference

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20 February 2020

0 references

0 references

1

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20 February 2020

Dwaipayan Sen

3

1 reference

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20 February 2020

author name string

Balaji Balakrishnan

2

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20 February 2020

Sanjay Kumar

4

1 reference

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20 February 2020

Alok Srivastava

5

1 reference

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20 February 2020

Giridhara R Jayandharan

6

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20 February 2020

publication date

10 September 2013

1 reference

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Reviews in Medical Virology

20 February 2020

published in

1 reference

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20 February 2020

volume

23

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20 February 2020

issue

6

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20 February 2020

page(s)

399-413

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The AAV vector toolkit: poised at the clinical crossroads

20 February 2020

cites work

1 reference

Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

21 January 2018

1 reference

Current advances in retroviral gene therapy

21 January 2018

1 reference

Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors

21 January 2018

1 reference

Gene therapy using adeno-associated virus vectors

21 January 2018

1 reference

Transient transfection methods for clinical adeno-associated viral vector production

21 January 2018

1 reference

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

21 January 2018

1 reference

Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection

21 January 2018

1 reference

Dystrophin immunity in Duchenne's muscular dystrophy.

21 January 2018

1 reference

Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors

21 January 2018

1 reference

Adenovirus-associated virus vector-mediated gene transfer in hemophilia B

21 January 2018

1 reference

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

21 January 2018

1 reference

CD8(+) T-cell responses to adeno-associated virus capsid in humans

21 January 2018

1 reference

Immune responses to AAV in a phase I study for Canavan disease.

21 January 2018

1 reference

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

21 January 2018

1 reference

AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

21 January 2018

1 reference

Immunity to adeno-associated virus vectors in animals and humans: a continued challenge

21 January 2018

1 reference

CD40 ligand-dependent activation of cytotoxic T lymphocytes by adeno-associated virus vectors in vivo: role of immature dendritic cells

21 January 2018

1 reference

Complement is an essential component of the immune response to adeno-associated virus vectors

21 January 2018

1 reference

Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors

21 January 2018

1 reference

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver

21 January 2018

1 reference

RETRACTED: Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy

21 January 2018

1 reference

Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors

21 January 2018

1 reference

Pathogen recognition and inflammatory signaling in innate immune defenses

21 January 2018

1 reference

The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice

21 January 2018

1 reference

Innate Immune Responses to AAV Vectors

21 January 2018

1 reference

Intracellular trafficking of adeno-associated viral vectors.

21 January 2018

1 reference

Intracellular transport of recombinant adeno-associated virus vectors

21 January 2018

1 reference

The mammalian unfolded protein response

21 January 2018

1 reference

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

21 January 2018

1 reference

The unfolded protein response: how protein folding became a restrictive aspect for innate immunity and B lymphocytes

21 January 2018

1 reference

Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2

21 January 2018

1 reference

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression

21 January 2018

1 reference

Trans-Golgi network sorting

21 January 2018

1 reference

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

Cloning of an avian adeno-associated virus (AAAV) and generation of recombinant AAAV particles

21 January 2018

1 reference

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

21 January 2018

1 reference

Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses.

21 January 2018

1 reference

Examining the cross-reactivity and neutralization mechanisms of a panel of mAbs against adeno-associated virus serotypes 1 and 5.

21 January 2018

1 reference

Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy

21 January 2018

1 reference

Assessment of a passive immunity mouse model to quantitatively analyze the impact of neutralizing antibodies on adeno-associated virus-mediated gene transfer

21 January 2018

1 reference

Impact of pre-existing immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors

21 January 2018

1 reference

Adeno-associated virus antibody profiles in newborns, children, and adolescents

21 January 2018

1 reference

Humoral and cellular capsid-specific immune responses to adeno-associated virus type 1 in randomized healthy donors

21 January 2018

1 reference

Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

21 January 2018

1 reference

MHC molecules and microbial antigen processing in phagosomes

21 January 2018

1 reference

Adeno-associated virus capsid antigen presentation is dependent on endosomal escape

21 January 2018

1 reference

Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors

21 January 2018

1 reference

Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo

21 January 2018

1 reference

Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles

21 January 2018

1 reference

Cellular immune response to cryptic epitopes during therapeutic gene transfer

21 January 2018

1 reference

Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins

21 January 2018

1 reference

Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid

21 January 2018

1 reference

Impact of the underlying mutation and the route of vector administration on immune responses to factor IX in gene therapy for hemophilia B.

21 January 2018

1 reference

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.

21 January 2018

1 reference

Capsid-specific T-cell responses to natural infections with adeno-associated viruses in humans differ from those of nonhuman primates

21 January 2018

1 reference

AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cells

21 January 2018

1 reference

Safety and efficacy of gene transfer for Leber's congenital amaurosis

21 January 2018

1 reference

Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

21 January 2018

1 reference

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

21 January 2018

1 reference

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

21 January 2018

1 reference

Long-term correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy

21 January 2018

1 reference

Induction of immune tolerance to FIX following muscular AAV gene transfer is AAV-dose/FIX-level dependent

21 January 2018

1 reference

Nonredundant roles of IL-10 and TGF-β in suppression of immune responses to hepatic AAV-factor IX gene transfer

21 January 2018

1 reference

Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine

21 January 2018

1 reference

Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs

21 January 2018

1 reference

Improved Immunological Tolerance Following Combination Therapy with CTLA-4/Ig and AAV-Mediated PD-L1/2 Muscle Gene Transfer.

21 January 2018

1 reference

Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy

21 January 2018

1 reference

Transient immunomodulation allows repeated injections of AAV1 and correction of muscular dystrophy in multiple muscles.

21 January 2018

1 reference

Proteasome inhibition is partially effective in attenuating pre-existing immunity against recombinant adeno-associated viral vectors

21 January 2018

1 reference

Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction.

21 January 2018

1 reference

Targeting signal transduction as a strategy to treat inflammatory diseases.

21 January 2018

1 reference

Dendritic cells: emerging pharmacological targets of immunosuppressive drugs

21 January 2018

1 reference

AAV2 vector harboring a liver-restricted promoter facilitates sustained expression of therapeutic levels of alpha-galactosidase A and the induction of immune tolerance in Fabry mice.

21 January 2018

1 reference

Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

21 January 2018

1 reference

Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver

21 January 2018

1 reference

PEG conjugation moderately protects adeno-associated viral vectors against antibody neutralization

21 January 2018

1 reference

Utility of PEGylated recombinant adeno-associated viruses for gene transfer.

21 January 2018

1 reference

Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses

21 January 2018

1 reference

Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure

21 January 2018

1 reference

Genetic modifications of the adeno-associated virus type 2 capsid reduce the affinity and the neutralizing effects of human serum antibodies

21 January 2018

1 reference

Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity

21 January 2018

1 reference

Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection

21 January 2018

1 reference

Mutations on the external surfaces of adeno-associated virus type 2 capsids that affect transduction and neutralization

21 January 2018

1 reference

Molecular evolution of adeno-associated virus for enhanced glial gene delivery

21 January 2018

1 reference

Directed evolution of adeno-associated virus yields enhanced gene delivery vectors

21 January 2018

1 reference

In vitro selection of viral vectors with modified tropism: the adeno-associated virus display

21 January 2018

1 reference

Optimization of stealth adeno-associated virus vectors by randomization of immunogenic epitopes

21 January 2018

1 reference

Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.

21 January 2018

1 reference

Bioengineering of AAV2 capsid at specific serine, threonine, or lysine residues improves its transduction efficiency in vitro and in vivo.

21 January 2018

1 reference

Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo

21 January 2018

1 reference

BALB/c mice show impaired hepatic tolerogenic response following AAV gene transfer to the liver

21 January 2018

1 reference

Clades of Adeno-associated viruses are widely disseminated in human tissues.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/RMV.1762

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24023004%20AND%20SRC:MED&resulttype=core&format=json

release_p7ejt2fo35ggze2wwoeuczgp7q

20 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/p7ejt2fo35ggze2wwoeuczgp7q

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

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