(Q34373001)

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Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma

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scholarly article

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21 March 2020

Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma (English)

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21 March 2020

phase I clinical trial

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hydroxychloroquine

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pharmacodynamics

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inferred from title

Douglas H Thamm

6

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21 March 2020

author name string

Rebecca A Barnard

1

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21 March 2020

Luke A Wittenburg

2

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21 March 2020

Ravi K Amaravadi

3

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21 March 2020

Daniel L Gustafson

4

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21 March 2020

Andrew Thorburn

5

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21 March 2020

publication date

20 May 2014

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21 March 2020

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21 March 2020

10

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21 March 2020

8

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21 March 2020

1415-1425

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21 March 2020

describes a project that uses

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11 June 2022

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based on heuristic

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A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

1 reference

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6 July 2018

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

1 reference

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6 July 2018

Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma

1 reference

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6 July 2018

Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma

1 reference

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6 July 2018

The variability of autophagy and cell death susceptibility: Unanswered questions

1 reference

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6 July 2018

Direct uptake and degradation of DNA by lysosomes

1 reference

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ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis

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Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy

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6 July 2018

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6 July 2018

Chloroquine in cancer therapy: a double-edged sword of autophagy.

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6 July 2018

Guidelines for the use and interpretation of assays for monitoring autophagy

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Failure of amino acid homeostasis causes cell death following proteasome inhibition.

1 reference

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6 July 2018

Development of a limited-sampling model for prediction of doxorubicin exposure in dogs.

1 reference

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6 July 2018

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

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6 July 2018

Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation

1 reference

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6 July 2018

Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance

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6 July 2018

Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models

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6 July 2018

Successful treatment of a novel generalized variant of canine discoid lupus erythematosus with oral hydroxychloroquine.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203518

6 July 2018

Epigenetics and B-cell lymphoma

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6 July 2018

Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203518

6 July 2018

Phase I pharmacokinetic and pharmacodynamic evaluation of combined valproic acid/doxorubicin treatment in dogs with spontaneous cancer.

1 reference

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Doxorubicin and cyclophosphamide for the treatment of canine lymphoma: a randomized, placebo-controlled study.

1 reference

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6 July 2018

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

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6 July 2018

Exfoliative cutaneous lupus erythematosus in German shorthaired pointer dogs: disease development, progression and evaluation of three immunomodulatory drugs (ciclosporin, hydroxychloroquine, and adalimumab) in a controlled environment

1 reference

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6 July 2018

Preclinical investigation of PEGylated tumor necrosis factor alpha in dogs with spontaneous tumors: phase I evaluation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203518

6 July 2018

Methods in mammalian autophagy research

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Hypermethylation of the DLC1 CpG island does not alter gene expression in canine lymphoma

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Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature

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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

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Autophagy in cell death: an innocent convict?

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1 reference

https://pubmed.ncbi.nlm.nih.gov/24991836

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based on heuristic

inferred from PubMed ID database lookup

Evaluation of the effects of dietary n-3 fatty acid supplementation on the pharmacokinetics of doxorubicin in dogs with lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24991836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/AUTO.29165

1 reference

Europe PubMed Central

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21 March 2020

1 reference

Europe PubMed Central

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21 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24991836%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

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