(Q34372987)

English

Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma (English)

1 reference

Europe PubMed Central

1 August 2017

phase I clinical trial

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hydroxychloroquine

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Andrea B. Troxel

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Andrea B Troxel

10

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16

object named as

Abass Alavi

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Europe PubMed Central

1 August 2017

author name string

Reshma Rangwala

1

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Europe PubMed Central

1 August 2017

Yunyoung C Chang

2

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Europe PubMed Central

1 August 2017

Janice Hu

3

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Europe PubMed Central

1 August 2017

Kenneth M Algazy

4

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Europe PubMed Central

1 August 2017

Tracey L Evans

5

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Europe PubMed Central

1 August 2017

Leslie A Fecher

6

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Europe PubMed Central

1 August 2017

Lynn M Schuchter

7

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Europe PubMed Central

1 August 2017

Drew A Torigian

8

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Europe PubMed Central

1 August 2017

Jeffrey T Panosian

9

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Europe PubMed Central

1 August 2017

Kay-See Tan

11

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Europe PubMed Central

1 August 2017

Daniel F Heitjan

12

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Europe PubMed Central

1 August 2017

Angela M DeMichele

13

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Europe PubMed Central

1 August 2017

David J Vaughn

14

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Europe PubMed Central

1 August 2017

Maryann Redlinger

15

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Europe PubMed Central

1 August 2017

Jonathon Kaiser

17

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Europe PubMed Central

1 August 2017

Laura Pontiggia

18

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Europe PubMed Central

1 August 2017

Lisa E Davis

19

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Europe PubMed Central

1 August 2017

Peter J O'Dwyer

20

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Europe PubMed Central

1 August 2017

Ravi K Amaravadi

21

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Europe PubMed Central

1 August 2017

publication date

20 May 2014

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1 August 2017

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Europe PubMed Central

1 August 2017

10

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Europe PubMed Central

1 August 2017

8

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Europe PubMed Central

1 August 2017

1391-1402

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Europe PubMed Central

1 August 2017

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Overview of positron emission tomography, hybrid positron emission tomography instrumentation, and positron emission tomography quantification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Autophagy modulation as a potential therapeutic target for diverse diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Temsirolimus: a safety and efficacy review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Deconvoluting the context-dependent role for autophagy in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

mTOR signaling in growth control and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Targeting PI3 kinase/AKT/mTOR signaling in cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Phase I study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Rapamycin passes the torch: a new generation of mTOR inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Automatic volume delineation in oncological PET. Evaluation of a dedicated software tool and comparison with manual delineation in clinical data sets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Principles and current strategies for targeting autophagy for cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Akt and autophagy cooperate to promote survival of drug-resistant glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

6 July 2018

Statistical properties of the traditional algorithm-based designs for phase I cancer clinical trials.

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.29119

21 January 2018

Feasibility and performance of novel software to quantify metabolically active volumes and 3D partial volume corrected SUV and metabolic volumetric products of spinal bone marrow metastases on 18F-FDG-PET/CT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4203516

27 October 2018

Whole-body metabolic tumour volume of 18F-FDG PET/CT improves the prediction of prognosis in small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24991838

12 December 2020

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Identifiers

10.4161/AUTO.29119

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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