(Q34378106)

1 August 2017

Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds (English)

1 reference

1 August 2017

Javier Lopez-Rios

3

0 references

Nicolas Matt

object named as

Nicolas Matt

5

0 references

Aimée Zuniga

object named as

Aimée Zuniga

1

0 references

Rolf Zeller

object named as

Rolf Zeller

6

0 references

author name string

Frédéric Laurent

2

1 reference

PubMed ID

22888807

1 August 2017

Christian Klasen

4

1 reference

1 August 2017

13 August 2012

1 reference

BMC Developmental Biology

1 August 2017

1 reference

1 August 2017

12

1 reference

1 August 2017

23

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-213x-12-23

1 August 2017

0 references

cites work

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GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis

6 July 2018

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Opposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactyly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

A regulatory archipelago controls Hox genes transcription in digits

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

A user's guide to the encyclopedia of DNA elements (ENCODE)

6 July 2018

1 reference

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cis-regulatory mutations are a genetic cause of human limb malformations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Enhancer function: new insights into the regulation of tissue-specific gene expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Functional analysis of CTCF during mammalian limb development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Control of vertebrate Hox clusters by remote and global cis-acting regulatory sequences.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

The temporal dynamics of vertebrate limb development, teratogenesis and evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Vertebrate limb bud development: moving towards integrative analysis of organogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Long-range regulation at the SOX9 locus in development and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Formin1 disruption confers oligodactylism and alters Bmp signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

LIM homeobox transcription factors integrate signaling events that control three-dimensional limb patterning and growth.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

The pectoral fin of Panderichthys and the origin of digits

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Identification of genes associated with regenerative success of Xenopus laevis hindlimbs.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Point mutations in a distant sonic hedgehog cis-regulator generate a variable regulatory output responsible for preaxial polydactyly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Clustal W and Clustal X version 2.0

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Shh and Gremlin1 chromosomal landscapes in development and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Regulation of Gremlin expression in the posterior limb bud.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

A global control region defines a chromosomal regulatory landscape containing the HoxD cluster

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Sonic hedgehog signaling is essential for hair development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Transposon tools for recombinant DNA manipulation: characterization of transcriptional regulators from yeast, Xenopus, and mouse.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3541112

Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.

6 July 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-12-23

Identification of spontaneous mutations within the long-range limb-specific Sonic hedgehog enhancer (ZRS) that alter Sonic hedgehog expression in the chicken limb mutants oligozeugodactyly and silkie breed

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-12-23

Chromosomal dynamics at the Shh locus: limb bud-specific differential regulation of competence and active transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-12-23

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-12-23

Regulated expression pattern of gremlin during zebrafish development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-12-23

The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-12-23

Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1471-213X-12-23

High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion

21 January 2018

1 reference

12 December 2020

Generation of Smad4/Dpc4 conditional knockout mice

1 reference

12 December 2020

Rapid and accurate determination of zygosity in transgenic animals by real-time quantitative PCR

1 reference

12 December 2020

Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancer

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-213X-12-23

1 reference

PubMed ID

22888807

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference

PubMed ID

22888807