(Q34386836)

1 August 2017

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title

Optimization of metabolic stability as a goal of modern drug design (English)

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1 August 2017

Thompson TN

1

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1 August 2017

publication date

1 September 2001

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Medicinal Research Reviews

1 August 2017

published in

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1 August 2017

volume

21

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1 August 2017

issue

5

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1 August 2017

page(s)

412-449

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Role of metabolism and pharmacokinetic studies in the discovery of new drugs--present and future perspectives

1 August 2017

cites work

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The use of in vitro metabolism studies in the understanding of new drugs

21 January 2018

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Design of drugs through a consideration of drug metabolism and pharmacokinetics

21 January 2018

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Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics

21 January 2018

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Early ADME in support of drug discovery: the role of metabolic stability studies

21 January 2018

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High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery

21 January 2018

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Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)

21 January 2018

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Preclinical drug metabolism in the age of high-throughput screening: an industrial perspective

21 January 2018

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High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds

21 January 2018

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The use of in vitro metabolism techniques in the planning and interpretation of drug safety studies

21 January 2018

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Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

21 January 2018

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Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

21 January 2018

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Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

21 January 2018

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Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

21 January 2018

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Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes

21 January 2018

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Synthetic strategies to lower affinity for CYP2D6.

21 January 2018

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Hydrolysis of carbonates, thiocarbonates, carbamates, and carboxylic esters of alpha-naphthol, beta-naphthol, and p-nitrophenol by human, rat, and mouse liver carboxylesterases

21 January 2018

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Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication

21 January 2018

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Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime

21 January 2018

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Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy

21 January 2018

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Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs

21 January 2018

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Development of orally active oxytocin antagonists: studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl]piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines

21 January 2018

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Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties

21 January 2018

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Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability

21 January 2018

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Isoindol-1-one analogues of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridyl)-p-iodobenzamido]ethyl]pipera zine (p-MPPI) as 5-HT1A receptor ligands

21 January 2018

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High-throughput high-performance liquid chromatography/mass spectrometry for modern drug discovery

21 January 2018

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Quantitative structure-activity relationships of cytochrome P-450.

21 January 2018

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Structural characteristics of human P450s involved in drug metabolism: QSARs and lipophilicity profiles

21 January 2018

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Computational methods for the prediction of 'drug-likeness'

21 January 2018

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QSAR model for drug human oral bioavailability.

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

21 January 2018

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Advances in drug metabolism screening

21 January 2018

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Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

21 January 2018

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Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6

21 January 2018

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A novel approach to predicting P450 mediated drug metabolism. CYP2D6 catalyzed N-dealkylation reactions and qualitative metabolite predictions using a combined protein and pharmacophore model for CYP2D6

21 January 2018

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Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4

21 January 2018

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Discovery of bioavailable inhibitors of secretory phospholipase A2

21 January 2018

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Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability

21 January 2018

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In vitro stability and intestinal absorption characteristics of hexapeptide endothelin receptor antagonists

21 January 2018

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Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors

21 January 2018

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On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and metabolism

21 January 2018

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Use and value of metabolism databases

21 January 2018

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Predicting the regioselectivity and stereoselectivity of cytochrome P450-mediated reactions: structural models for bioactivation reactions.

21 January 2018

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Predicting human oral bioavailability of a compound: development of a novel quantitative structure-bioavailability relationship

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.1017

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release_yts5joxaujddphdodgcbq5mjd4

1 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/yts5joxaujddphdodgcbq5mjd4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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