(Q34396839)

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Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis

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scholarly article

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Europe PubMed Central

PubMed publication ID

1 August 2017

Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis (English)

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Europe PubMed Central

PubMed publication ID

1 August 2017

endoplasmic reticulum

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inferred from title

4

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31 May 2020

8

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31 May 2020

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Shan Jiang

1

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31 May 2020

Cheng Yan

2

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31 May 2020

Qi-chen Fang

3

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31 May 2020

Yong-liang Zhang

5

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31 May 2020

Yang Liu

6

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31 May 2020

Yi-ping Deng

7

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31 May 2020

Jing-qi Liu

9

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31 May 2020

Hua-ting Li

10

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31 May 2020

Liu Yang

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31 May 2020

Jian Zhou

12

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31 May 2020

Zhi Dai

13

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31 May 2020

Yong Liu

14

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31 May 2020

Wei-ping Jia

15

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31 May 2020

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publication date

28 August 2014

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1 August 2017

Journal of Biological Chemistry

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31 May 2020

289

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31 May 2020

43

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31 May 2020

29751-29765

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31 May 2020

An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice

1 reference

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6 July 2018

Fibroblast growth factor 21 is induced by endoplasmic reticulum stress

1 reference

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The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling

1 reference

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Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

1 reference

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Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

1 reference

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6 July 2018

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

1 reference

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6 July 2018

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation.

1 reference

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6 July 2018

The unfolded protein response: from stress pathway to homeostatic regulation

1 reference

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6 July 2018

Circulating fibroblast growth factor 21 levels are closely associated with hepatic fat content: a cross-sectional study

1 reference

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PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism

1 reference

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6 July 2018

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

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Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

1 reference

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6 July 2018

Endoplasmic reticulum stress in liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

6 July 2018

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

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Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

6 July 2018

Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

6 July 2018

Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

6 July 2018

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

6 July 2018

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

6 July 2018

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

6 July 2018

Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

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Fibroblast growth factor 21 corrects obesity in mice

1 reference

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Regulation of hepatic lipogenesis by the transcription factor XBP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

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Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines.

1 reference

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Non-alcoholic fatty liver disease and the metabolic syndrome: an update

1 reference

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The role for endoplasmic reticulum stress in diabetes mellitus

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Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207989

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1 reference

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1 reference

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BetaKlotho is required for metabolic activity of fibroblast growth factor 21

1 reference

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FGF-21 as a novel metabolic regulator

1 reference

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1 reference

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1 reference

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The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

1 reference

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Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus

1 reference

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Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1 reference

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Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

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Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

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The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

1 reference

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Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

21 January 2018

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

21 January 2018

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

21 January 2018

Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivity in Chinese subjects

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

21 January 2018

Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

21 January 2018

High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

21 January 2018

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

21 January 2018

Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.565960

21 January 2018

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25170079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II

1 reference

https://pubmed.ncbi.nlm.nih.gov/25170079

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.565960

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25170079%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25170079%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25170079%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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