(Q34400187)

1 August 2017

title

Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis (English)

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1 August 2017

7

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1 August 2017

Stefan Legewie

6

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Peter K. Sorger

object named as

Peter K Sorger

5

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author name string

Stefan M Kallenberger

1

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1 August 2017

Joël Beaudouin

2

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1 August 2017

Juliane Claus

3

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1 August 2017

Carmen Fischer

4

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1 August 2017

publication date

11 March 2014

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1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

316

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1 August 2017

page(s)

ra23

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describes a project that uses

1 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4208692/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis

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A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death

6 July 2018

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Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model

6 July 2018

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Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis

6 July 2018

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TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies

6 July 2018

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Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Measuring and modeling apoptosis in single cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Regulation of the Apaf-1-caspase-9 apoptosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

CD95 promotes tumour growth

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Dynamics and variability of ERK2 response to EGF in individual living cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

A new C-terminal cleavage product of procaspase-8, p30, defines an alternative pathway of procaspase-8 activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Modeling a snap-action, variable-delay switch controlling extrinsic cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Dynamical modeling and multi-experiment fitting with PottersWheel

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Yes and PI3K bind CD95 to signal invasion of glioblastoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Variability and memory of protein levels in human cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Computational processing and error reduction strategies for standardized quantitative data in biological networks

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

The protein structures that shape caspase activity, specificity, activation and inhibition

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Activation of caspases-8 and -10 by FLIP(L).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Formation of stacked ER cisternae by low affinity protein interactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Interdimer processing mechanism of procaspase-8 activation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Insights into the regulatory mechanism for caspase-8 activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

A unified model for apical caspase activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Rapid caspase-3 activation during apoptosis revealed using fluorescence-resonance energy transfer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Identification and characterization of a ligand-independent oligomerization domain in the extracellular region of the CD95 death receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

The atomic-resolution structure of human caspase-8, a key activator of apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Death receptors: signaling and modulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4208692

Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.

6 July 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004738

Activation of initiator caspases through a stable dimeric intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004738

Studies of the molecular mechanism of caspase-8 activation by solution NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004738

Role of proteolysis in caspase-8 activation and stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004738

Bistability analyses of a caspase activation model for receptor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004738

TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004738

Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004738

10.1126/SCISIGNAL.2004738

21 January 2018

Identifiers

DOI

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1 August 2017

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1 August 2017

1 reference