(Q34401062)

1 August 2017

title

Nature of pharmacophore influences active site specificity of proteasome inhibitors (English)

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1 August 2017

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ChEBI release 2020-05-28

Paul P Geurink

7

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Martijn Verdoes

object named as

Martijn Verdoes

4

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Bogdan I Florea

object named as

Bogdan I Florea

9

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Herman S Overkleeft

object named as

Herman S Overkleeft

12

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author name string

Michael Screen

1

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1 August 2017

Matthew Britton

2

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1 August 2017

Sondra L Downey

3

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1 August 2017

Mathias J Voges

5

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1 August 2017

Annet E M Blom

6

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1 August 2017

Martijn D P Risseeuw

8

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1 August 2017

Wouter A van der Linden

10

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1 August 2017

Alexandre A Pletnev

11

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1 August 2017

Alexei F Kisselev

13

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1 August 2017

language of work or name

English

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publication date

11 October 2010

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Journal of Biological Chemistry

1 August 2017

published in

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1 August 2017

volume

285

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1 August 2017

issue

51

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1 August 2017

page(s)

40125-40134

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A panel of subunit-selective activity-based proteasome probes

1 August 2017

cites work

1 reference

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6 July 2018

1 reference

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Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites

6 July 2018

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Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

6 July 2018

1 reference

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CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib

6 July 2018

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Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors

6 July 2018

1 reference

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A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo

6 July 2018

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

6 July 2018

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Peptidyl vinyl ester derivatives: new class of selective inhibitors of proteasome trypsin-like activity

6 July 2018

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Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach

6 July 2018

1 reference

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The proteasome: a suitable antineoplastic target

6 July 2018

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Proteasome inhibitors: from research tools to drug candidates

6 July 2018

1 reference

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26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

6 July 2018

1 reference

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Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants

6 July 2018

1 reference

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The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing

6 July 2018

1 reference

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Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation

6 July 2018

1 reference

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Structure of 20S proteasome from yeast at 2.4 A resolution

6 July 2018

1 reference

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Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly

6 July 2018

1 reference

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Cathepsin S and related lysosomal endopeptidases.

6 July 2018

1 reference

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Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

6 July 2018

1 reference

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Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide alpha',beta'-epoxyketones.

21 January 2018

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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

21 January 2018

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Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome.

21 January 2018

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Cell-based bioluminescent assays for all three proteasome activities in a homogeneous format.

21 January 2018

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Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

21 January 2018

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Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation.

21 January 2018

1 reference

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A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.160606

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20937826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20937826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.160606

1 reference

1 August 2017

1 reference

1 August 2017

1 reference