(Q45969598)

18 December 2017

title

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. (English)

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18 December 2017

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18 December 2017

Marcus Groettrup

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object named as

Marcus Groettrup

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author name string

Tony Muchamuel

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18 December 2017

Monette A Aujay

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18 December 2017

Erika Suzuki

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18 December 2017

Khalid W Kalim

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18 December 2017

Christoph Lauer

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18 December 2017

Catherine Sylvain

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18 December 2017

Eileen R Ring

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18 December 2017

Jamie Shields

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18 December 2017

Jing Jiang

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18 December 2017

Peter Shwonek

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18 December 2017

Francesco Parlati

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18 December 2017

Susan D Demo

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18 December 2017

Mark K Bennett

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18 December 2017

Christopher J Kirk

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18 December 2017

language of work or name

English

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publication date

14 June 2009

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18 December 2017

published in

Nature Medicine

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18 December 2017

volume

15

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18 December 2017

issue

7

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18 December 2017

page(s)

781-787

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18 December 2017

https://scigraph.springernature.com/pub.10.1038/nm.1978

exact match

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cites work

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

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12 December 2020

Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells

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12 December 2020

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

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12 December 2020

The ubiquitin-proteasome pathway and pathogenesis of human diseases

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12 December 2020

Proteasome inhibition: a new anti-inflammatory strategy

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12 December 2020

The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events

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12 December 2020

No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes

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12 December 2020

Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy

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12 December 2020

Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis

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12 December 2020

The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis

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12 December 2020

Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate

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12 December 2020

Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus

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12 December 2020

The interferon-gamma-inducible 11 S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20 S proteasome in vitro

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12 December 2020

20S proteasome and its inhibitors: crystallographic knowledge for drug development

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12 December 2020

Approval summary for bortezomib for injection in the treatment of multiple myeloma

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12 December 2020

Role of immunoproteasomes in cross-presentation

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12 December 2020

Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits

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12 December 2020

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

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12 December 2020

LMP2-specific inhibitors: chemical genetic tools for proteasome biology

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12 December 2020

T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens

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12 December 2020

The proteasome: a central regulator of inflammation and macrophage function

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12 December 2020

Altered peptidase and viral-specific T cell response in LMP2 mutant mice.

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12 December 2020

Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.

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12 December 2020

An altered T cell repertoire in MECL-1-deficient mice

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12 December 2020

Antigen processing by the proteasome

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12 December 2020

Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency

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12 December 2020

Intermediate-type 20 S proteasomes in HeLa cells: "asymmetric" subunit composition, diversity and adaptation

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12 December 2020

Beta 2 subunit propeptides influence cooperative proteasome assembly

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12 December 2020

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

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12 December 2020

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome

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12 December 2020

MHC class I expression in mice lacking the proteasome subunit LMP-7

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12 December 2020

Immunoproteasomes are essential for clearance of Listeria monocytogenes in nonlymphoid tissues but not for induction of bacteria-specific CD8+ T cells

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12 December 2020

Genomic organization and tissue expression of the mouse proteasome gene Lmp-7.

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12 December 2020

Proteasome and peptidase function in MHC-class-I-mediated antigen presentation

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12 December 2020

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

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12 December 2020

Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination

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12 December 2020

Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liver

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12 December 2020

Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens.

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12 December 2020

Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib

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12 December 2020

Identifiers

DOI

10.1038/NM.1978

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18 December 2017

Dimensions Publication ID

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18 December 2017