(Q34414372)

2 August 2017

title

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects (English)

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2 August 2017

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Alexandros Makriyannis

15

object named as

Alexandros Makriyannis

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2 August 2017

Douglas Osei-Hyiaman

7

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Resat Cinar

object named as

Resat Cinar

5

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Benjamin Cravatt

14

object named as

Benjamin F Cravatt

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2 August 2017

12

Karel Pacak

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2 August 2017

10

Judith Harvey-White

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2 August 2017

Grzegorz Godlewski

1

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2 August 2017

Shakiru O Alapafuja

2

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2 August 2017

Sándor Bátkai

3

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2 August 2017

Spyros P Nikas

4

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2 August 2017

László Offertáler

6

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2 August 2017

Jie Liu

8

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2 August 2017

Bani Mukhopadhyay

9

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2 August 2017

Joseph Tam

11

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2 August 2017

Jacqueline L Blankman

13

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2 August 2017

George Kunos

16

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2 August 2017

publication date

1 November 2010

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2 August 2017

published in

Chemistry and Biology

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2 August 2017

volume

17

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2 August 2017

issue

11

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2 August 2017

page(s)

1256-1266

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Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

2 August 2017

cites work

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The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

6 July 2018

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FAAH deficiency promotes energy storage and enhances the motivation for food

6 July 2018

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Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats

6 July 2018

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Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Pharmacotherapeutic modulation of the endocannabinoid signalling system in psychiatric disorders: drug-discovery strategies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

6 July 2018

1 reference

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Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

6 July 2018

1 reference

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Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration

6 July 2018

1 reference

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The endocannabinoid system as an emerging target of pharmacotherapy

6 July 2018

1 reference

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The cannabinergic system as a target for anti-inflammatory therapies

6 July 2018

1 reference

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The sympathetic control of blood pressure

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Cannabinoid receptor signaling.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.

6 July 2018

1 reference

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Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

6 July 2018

1 reference

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Modulation of anxiety through blockade of anandamide hydrolysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Brain monoglyceride lipase participating in endocannabinoid inactivation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Pertussis toxin-sensitive G-proteins and regulation of blood pressure in the spontaneously hypertensive rat

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Enhanced expression of Gi-protein precedes the development of blood pressure in spontaneously hypertensive rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

A human fatty acid amide hydrolase (FAAH) functional gene variant is associated with lower blood pressure in young males.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Impairment of sympathetic baroreceptor reflexes in obese Zucker rats.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Mechanism of the hypotensive action of anandamide in anesthetized rats

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3003779

Analysis of anandamide, an endogenous cannabinoid substance, and of other natural N-acylethanolamines

27 October 2018

1 reference

12 December 2020

Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor

1 reference

12 December 2020

Overexpression of Gi-proteins precedes the development of DOCA-salt-induced hypertension: relationship with adenylyl cyclase

1 reference

12 December 2020

Enhanced expression of Gialpha protein and adenylyl cyclase signaling in aortas from 1 kidney 1 clip hypertensive rats

1 reference

12 December 2020

10.1016/J.CHEMBIOL.2010.08.013

Identifiers

DOI

1 reference

2 August 2017

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2 August 2017

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