(Q34417631)

2 August 2017

title

Development of inhibitors as research tools for carbohydrate-processing enzymes (English)

1 reference

2 August 2017

Tracey M Gloster

1

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2 August 2017

publication date

1 October 2012

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Biochemical Society Transactions

2 August 2017

published in

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2 August 2017

volume

40

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2 August 2017

issue

5

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2 August 2017

page(s)

913-928

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Human sperm binding is mediated by the sialyl-Lewis(x) oligosaccharide on the zona pellucida

2 August 2017

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A new sialidase mechanism: bacteriophage K1F endo-sialidase is an inverting glycosidase

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Divergence of Catalytic Mechanism within a Glycosidase Family Provides Insight into Evolution of Carbohydrate Metabolism by Human Gut Flora

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Glycosidase inhibition: assessing mimicry of the transition state

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Catalytic mechanism of enzymic glycosyl transfer

21 January 2018

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Rational design of potent sialidase-based inhibitors of influenza virus replication

21 January 2018

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Structural basis for oseltamivir resistance of influenza viruses

21 January 2018

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Recent developments of transition-state analogue glycosidase inhibitors of non-natural product origin

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Sugar-mimicking glycosidase inhibitors: bioactivity and application

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Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics

21 January 2018

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Ligand solvation in molecular docking.

21 January 2018

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Thermodynamics of binding of D-galactose and deoxy derivatives thereof to the L-arabinose-binding protein

21 January 2018

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Win some, lose some: enthalpy-entropy compensation in weak intermolecular interactions

21 January 2018

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Direct observation of the protonation state of an imino sugar glycosidase inhibitor upon binding

21 January 2018

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Snapshots along an enzymatic reaction coordinate: analysis of a retaining beta-glycoside hydrolase

21 January 2018

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Substrate distortion by a beta-mannanase: snapshots of the Michaelis and covalent-intermediate complexes suggest a B(2,5) conformation for the transition state

21 January 2018

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Visualizing the reaction coordinate of an O-GlcNAc hydrolase

21 January 2018

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Conformational analyses of the reaction coordinate of glycosidases

21 January 2018

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Mapping the conformational itinerary of beta-glycosidases by X-ray crystallography

21 January 2018

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Structural and biochemical evidence for a boat-like transition state in beta-mannosidases

21 January 2018

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Structural, thermodynamic, and kinetic analyses of tetrahydrooxazine-derived inhibitors bound to beta-glucosidases

21 January 2018

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Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases

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Structural rationale for low-nanomolar binding of transition state mimics to a family GH3 beta-D-glucan glucohydrolase from barley

21 January 2018

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Inhibition of the alpha-L-arabinofuranosidase III of Monilinia fructigena by 1,4-dideoxy-1,4-imino-L-threitol and 1,4-dideoxy-1,4-imino-L-arabinitol

21 January 2018

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The Intrinsic PkA-Values of Functional Groups in Enzymes: Improper Deductions from the Ph-Dependence of Steady-State Parameter

21 January 2018

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21 January 2018

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21 January 2018

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Reassessment of acarbose as a transition state analogue inhibitor of cyclodextrin glycosyltransferase

21 January 2018

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Thermodynamics of Inhibitor Binding to Mutant Forms of Glucoamylase from Aspergillus niger Determined by Isothermal Titration Calorimetry

21 January 2018

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The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

21 January 2018

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Ex vivo and in vivo effects of isofagomine on acid β-glucosidase variants and substrate levels in Gaucher disease

21 January 2018

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A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

21 January 2018

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Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

21 January 2018

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Three monophyletic superfamilies account for the majority of the known glycosyltransferases

21 January 2018

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Structure-guided identification of a new catalytic motif of oligosaccharyltransferase

21 January 2018

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Glycosyltransferases: structures, functions, and mechanisms

21 January 2018

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Trapping and characterization of covalent intermediates of mutant retaining glycosyltransferases.

21 January 2018

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Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase

21 January 2018

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Efficient sialyltransferase inhibitors based on glycosides of N-acetylglucosamine

21 January 2018

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A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry

21 January 2018

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Kinetic characterization of enzyme inhibitors using electrospray-ionization mass spectrometry coupled with multiple reaction monitoring

21 January 2018

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Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism

21 January 2018

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Synthesis of bisubstrate and donor analogues of sialyltransferase and their inhibitory activities

21 January 2018

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Systematic synthesis of bisubstrate-type inhibitors of N-acetylglucosaminyltransferases

21 January 2018

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Mechanistic insight into enzymatic glycosyl transfer with retention of configuration through analysis of glycomimetic inhibitors

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120201

Structural and mechanistic basis for a new mode of glycosyltransferase inhibition

21 January 2018

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A new concept for glycosyltransferase inhibitors: nonionic mimics of the nucleotide donor of the human blood group B galactosyltransferase

21 January 2018

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The Hexapeptide inhibitor of Galbeta 1,3GalNAc-specific alpha 2,3-sialyltransferase as a generic inhibitor of sialyltransferases

21 January 2018

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Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors.

21 January 2018

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Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120201

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120201

O-linked N-acetylglucosaminyltransferase inhibition prevents G2/M transition in Xenopus laevis oocytes

21 January 2018

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Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.

21 January 2018

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Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120201

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120201

Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen

21 January 2018

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The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120201

An efficient approach to the discovery of potent inhibitors against glycosyltransferases.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120201

Discovery of O-GlcNAc transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120201

D-Gluconhydroximo-1,5-lactam and RelatedN-Arylcarbamates Theoretical Calculations, Structure, Synthesis, and Inhibitory Effect on ?-Glucosidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120201

Retaining Glycosyltransferase Mechanism Studied by QM/MM Methods: Lipopolysaccharyl-α-1,4-galactosyltransferase C Transfers α-Galactose via an Oxocarbenium Ion-like Transition State

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120201

An Unusual Mechanism of Glycoside Hydrolysis Involving Redox and Elimination Steps by a Family 4 β-Glycosidase fromThermotoga maritima

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120201

Nature of Forces between Large Molecules of Biological Interest*

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120201

21 January 2018

Identifiers

DOI

10.1042/BST20120201

1 reference

2 August 2017

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