(Q34418677)

2 August 2017

title

Minimally invasive mutagenesis gives rise to a biosynthetic polyketide library. (English)

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2 August 2017

Susanna Kushnir

1

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2 August 2017

Uschi Sundermann

2

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2 August 2017

Samir Yahiaoui

3

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2 August 2017

Andreas Brockmeyer

4

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2 August 2017

Petra Janning

5

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2 August 2017

Frank Schulz

6

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2 August 2017

language of work or name

English

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publication date

20 September 2012

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Angewandte Chemie International Edition

2 August 2017

published in

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volume

51

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2 August 2017

issue

42

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2 August 2017

page(s)

10664-10669

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Merging chemical synthesis and biosynthesis: a new chapter in the total synthesis of natural products and natural product libraries

2 August 2017

cites work

1 reference

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The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases.

21 January 2018

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Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

21 January 2018

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Engineering of complex polyketide biosynthesis--insights from sequencing of the monensin biosynthetic gene cluster

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Intermediates released from a polyether-producing polyketide synthase provide insight into the mechanism of oxidative cyclization

21 January 2018

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21 January 2018

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Metabolic engineering for the production of natural products.

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Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

21 January 2018

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Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase

21 January 2018

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Effect of glucose limitation and specific mutations in the module 5 enoyl reductase domains in the nystatin and amphotericin polyketide synthases on polyene macrolide biosynthesis

21 January 2018

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Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked

21 January 2018

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Biosynthesis of polyketides by trans-AT polyketide synthases

21 January 2018

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Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting

21 January 2018

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Improvement of a stereoselective biocatalytic synthesis by substrate and enzyme engineering: 2-hydroxy-(4'-oxocyclohexyl)acetonitrile as the model.

21 January 2018

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Polyketide proofreading by an acyltransferase-like enzyme

21 January 2018

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Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin

21 January 2018

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Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively.

21 January 2018

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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

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Rational design and assembly of synthetic trimodular polyketide synthases.

21 January 2018

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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

21 January 2018

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From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201202438

1 reference

2 August 2017

1 reference