(Q36328793)

13 August 2017

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title

Combinatorial biosynthesis of reduced polyketides (English)

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13 August 2017

Peter F Leadlay

2

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author name string

Kira J Weissman

series ordinal

1

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PubMed ID

16322741

13 August 2017

language of work or name

English

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publication date

1 December 2005

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Nature Reviews Microbiology

13 August 2017

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13 August 2017

3

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13 August 2017

925-936

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13 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrmicro1287

13 August 2017

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Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272.

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Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.

21 January 2018

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Isolation and Characterization of New Epothilone Analogues from Recombinant Myxococcus xanthus Fermentations

21 January 2018

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Enzymology of acyl chain macrocyclization in natural product biosynthesis

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Polyene antibiotic biosynthesis gene clusters.

21 January 2018

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3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.

21 January 2018

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Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

21 January 2018

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The calicheamicin gene cluster and its iterative type I enediyne PKS

21 January 2018

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Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei

21 January 2018

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Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium

21 January 2018

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Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

21 January 2018

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Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species

21 January 2018

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Natural products--a simple model to explain chemical diversity

21 January 2018

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4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

21 January 2018

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Structural and functional organization of the animal fatty acid synthase

21 January 2018

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Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans

21 January 2018

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Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

21 January 2018

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The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum

21 January 2018

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Positive control of tylosin biosynthesis: pivotal role of TylR.

21 January 2018

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Biosynthesis of polyketides in heterologous hosts

21 January 2018

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Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea.

21 January 2018

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Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B.

21 January 2018

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Modification of post-PKS tailoring steps through combinatorial biosynthesis

21 January 2018

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Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthase.

21 January 2018

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Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

21 January 2018

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Active-site residue, domain and module swaps in modular polyketide synthases

21 January 2018

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Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts

21 January 2018

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A multiplasmid approach to preparing large libraries of polyketides

21 January 2018

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Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.

21 January 2018

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Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1287

Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins

21 January 2018

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Genetic approaches to polyketide antibiotics. 1.

21 January 2018

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Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms

21 January 2018

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Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery

21 January 2018

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Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

21 January 2018

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Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites

21 January 2018

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Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products

21 January 2018

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Phylogenetic analysis of polyketide synthase I domains from soil metagenomic libraries allows selection of promising clones

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1287

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1287

Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1287

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1287

A novel actinomycete strain de-replication approach based on the diversity of polyketide synthase and nonribosomal peptide synthetase biosynthetic pathways.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1287

Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula

21 January 2018

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Polyketide synthase genes from marine dinoflagellates.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1287

Expression of polyketide biosynthesis and regulatory genes in heterologous streptomycetes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRMICRO1287

Engineered biosynthesis of a complete macrolactone in a heterologous host

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Artificial chromosomes for antibiotic-producing actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

A new enzyme superfamily - the phosphopantetheinyl transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Cloning and heterologous expression of the epothilone gene cluster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Production of the potent antibacterial polyketide erythromycin C in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

A new logic for DNA engineering using recombination in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Evidence for a double-helical structure for modular polyketide synthases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

The structure of docking domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Molecular architecture and mechanism of an icosahedral pyruvate dehydrogenase complex: a multifunctional catalytic machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Mammalian fatty acid synthase: closure on a textbook mechanism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Improved bioconversion of 15-fluoro-6-deoxyerythronolide B to 15-fluoro-erythromycin A by overexpression of the eryK Gene in Saccharopolyspora erythraea

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

New erythromycin derivatives from Saccharopolyspora erythraea using sugar O-methyltransferases from the spinosyn biosynthetic gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

The Post-Polyketide Synthase Modification Steps in the Biosynthesis of the Antitumor Agent Ansamitocin by Actinosynnema pretiosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Polyketide and nonribosomal peptide antibiotics: modularity and versatility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Chemoenzymatic route to macrocyclic hybrid peptide/polyketide-like molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Evolving strategies for enzyme engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Directed Evolution and Biocatalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Probing the Breadth of Macrolide Glycosyltransferases: In Vitro Remodeling of a Polyketide Antibiotic Creates Active Bacterial Uptake and Enhances Potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

New PCR Primers for the Screening of NRPS and PKS-I Systems in Actinomycetes: Detection and Distribution of These Biosynthetic Gene Sequences in Major Taxonomic Groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Where will new antibiotics come from?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

A hybrid modular polyketide synthase obtained by domain swapping

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Biosynthesis of the enediyne antitumor antibiotic C-1027

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Polyketide biosynthesis: a millennium review

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Harnessing the biosynthetic code: combinations, permutations, and mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

A Novel Erythromycin, 6-Desmethyl Erythromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Molecular basis of Celmer’s rules: role of the ketosynthase domain in epimerisation and demonstration that ketoreductase domains can have altered product specificity with unnatural substrates

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Dissecting and exploiting intermodular communication in polyketide synthases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

The thioesterase of the erythromycin-producing polyketide synthase: mechanistic studies in vitro to investigate its mode of action and substrate specificity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

Recombinant polyketide synthesis in Streptomyces: engineering of improved host strains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1287

31 March 2020

Identifiers

DOI

10.1038/NRMICRO1287

1 reference

13 August 2017

1 reference

PubMed ID

16322741