(Q44552141)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Kenji Watanabe

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

5

Chaitan Khosla

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

Clay C C Wang

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

David E Cane

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

language of work or name

English

0 references

publication date

15 August 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

7 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

issue

43

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

page(s)

42020-42026

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

7 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Modular organization of genes required for complex polyketide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Cloning and heterologous expression of the epothilone gene cluster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Tolerance and specificity of polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Polyketide biosynthesis: a millennium review

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

From molecular to modular cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

The Claisen condensation in biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Dissecting and exploiting intermodular communication in polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Analysis of the Molecular Recognition Features of Individual Modules Derived from the Erythromycin Polyketide Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305339200

21 January 2018

Identifiers

DOI

10.1074/JBC.M305339200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12923197%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference