(Q44481272)

3 December 2017

title

Active-site residue, domain and module swaps in modular polyketide synthases (English)

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3 December 2017

author name string

Francesca Del Vecchio

1

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3 December 2017

Hrvoje Petkovic

2

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3 December 2017

Steven G Kendrew

3

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3 December 2017

Lindsey Low

4

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3 December 2017

Barrie Wilkinson

5

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3 December 2017

Rachel Lill

6

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3 December 2017

Jesús Cortés

7

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3 December 2017

Brian A M Rudd

8

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3 December 2017

Jim Staunton

9

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3 December 2017

Peter F Leadlay

10

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3 December 2017

publication date

14 June 2003

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Journal of Industrial Microbiology & Biotechnology

3 December 2017

published in

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3 December 2017

volume

30

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3 December 2017

issue

8

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3 December 2017

page(s)

489-494

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A hybrid modular polyketide synthase obtained by domain swapping

3 December 2017

cites work

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12 December 2020

Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases

1 reference

12 December 2020

Evidence for a double-helical structure for modular polyketide synthases.

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Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.

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12 December 2020

The mRNA for the 23S rRNA methylase encoded by the ermE gene of Saccharopolyspora erythraea is translated in the absence of a conventional ribosome-binding site.

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12 December 2020

The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component

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12 December 2020

Expression analysis of the tylosin-biosynthetic gene cluster: pivotal regulatory role of the tylQ product.

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12 December 2020

Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations.

1 reference

12 December 2020

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues.

1 reference

12 December 2020

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

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12 December 2020

Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.

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12 December 2020

Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector

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12 December 2020

Polyketide biosynthesis: a millennium review

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12 December 2020

Construction of new vectors for high-level expression in actinomycetes.

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12 December 2020

Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

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12 December 2020

Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases

1 reference

12 December 2020

Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase

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12 December 2020

Type I polyketide biosynthesis in bacteria (Part A--erythromycin biosynthesis).

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12 December 2020

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

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12 December 2020

Production of a novel polyketide through the construction of a hybrid polyketide synthase.

1 reference

12 December 2020

Role of linkers in communication between protein modules

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12 December 2020

Rapid evolution of a protein in vitro by DNA shuffling

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12 December 2020

Engineered intermodular and intramodular polyketide synthase fusions

1 reference

12 December 2020

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

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12 December 2020

10.1007/S10295-003-0062-0

Identifiers

DOI

0 references

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