(Q42456599)

English

Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase

scientific article published on December 2005

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scholarly article

1 reference

31 October 2017

Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase (English)

1 reference

31 October 2017

4

object named as

Chaitan Khosla

1 reference

31 October 2017

author name string

Jiaquan Wu

1

1 reference

31 October 2017

Toby J Zaleski

2

1 reference

31 October 2017

Chiara Valenzano

3

1 reference

31 October 2017

David E Cane

5

1 reference

31 October 2017

language of work or name

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publication date

1 December 2005

1 reference

31 October 2017

Journal of the American Chemical Society

1 reference

31 October 2017

127

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31 October 2017

17393-17404

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31 October 2017

49

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31 October 2017

Intermediates released from a polyether-producing polyketide synthase provide insight into the mechanism of oxidative cyclization

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Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase

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Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis

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Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

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Tolerance and specificity of polyketide synthases

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The X-ray structure of Brassica napus beta-keto acyl carrier protein reductase and its implications for substrate binding and catalysis

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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.

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A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity

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Post-translational modification of polyketide and nonribosomal peptide synthases

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Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

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An erythromycin analog produced by reprogramming of polyketide synthesis

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Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases

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Stereochemical problems in macrolide antibiotics

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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

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Modular organization of genes required for complex polyketide biosynthesis

1 reference

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28 May 2018

6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.

1 reference

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Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea

1 reference

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Isolation and characterization of 10-deoxymethynolide produced by Streptomyces venezuelae

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide

1 reference

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16 August 2018

Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates

1 reference

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Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase

1 reference

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The structure of (3R)-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Pseudomonas aeruginosa.

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Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase

1 reference

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Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.

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Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

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Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase

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A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

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Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase

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The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase

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Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides

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Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase.

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Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides.

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1 reference

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/16332089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MACROLIDE STEREOCHEMISTRY. 3. A CONFIGURATIONAL MODEL FOR MACROLIDE ANTIBIOTICS

1 reference

https://pubmed.ncbi.nlm.nih.gov/16332089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative modular polyketide synthase expression controls macrolactone structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/16332089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthesis of picromycin using 13C enriched precursors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16332089

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based on heuristic

inferred from PubMed ID database lookup

Mutagenesis of the dehydratase active site in the erythromycin-producing polyketide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16332089

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based on heuristic

inferred from PubMed ID database lookup

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16332089

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based on heuristic

inferred from PubMed ID database lookup

Engineered intermodular and intramodular polyketide synthase fusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/16332089

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA055672+

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31 October 2017

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31 October 2017

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31 October 2017

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