(Q34423288)

2 August 2017

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title

Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century (English)

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2 August 2017

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Mario R Capecchi

1

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2 August 2017

1 June 2005

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2 August 2017

Nature Reviews Genetics

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2 August 2017

6

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2 August 2017

507-512

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2 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrg1619

2 August 2017

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High efficiency transformation by direct microinjection of DNA into cultured mammalian cells

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Genetic transformation of mouse embryos by microinjection of purified DNA

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Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA

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Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus

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Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules

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Transformation of yeast

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High frequency targeting of genes to specific sites in the mammalian genome

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Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

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Establishment in culture of pluripotential cells from mouse embryos

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Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

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Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

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High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors

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Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus

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Location of crossovers during gene targeting with insertion and replacement vectors

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Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells.

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Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells

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Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells.

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A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

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Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.

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Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

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The knockout mouse project

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

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Targeting genes for self-excision in the germ line

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Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids

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Fgf8 is required for outgrowth and patterning of the limbs

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Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge

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Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod

21 January 2018

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Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11

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Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton

21 January 2018

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Hoxb8 is required for normal grooming behavior in mice

21 January 2018

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Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.

21 January 2018

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Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.

21 January 2018

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Maintenance of functional equivalence during paralogous Hox gene evolution

21 January 2018

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Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays

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Analysis of Homologous Recombination in Cultured Mammalian Cells

31 March 2020

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Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRG1619

1 reference

PubMed ID

15931173

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

15931173