(Q34424253)

2 August 2017

title

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease (English)

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2 August 2017

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Pamela Maher

1

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2 August 2017

Richard Dargusch

2

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2 August 2017

Laszlo Bodai

3

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2 August 2017

Paul E Gerard

4

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2 August 2017

Judith M Purcell

5

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2 August 2017

J Lawrence Marsh

6

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2 August 2017

language of work or name

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15 October 2010

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2 August 2017

published in

Human Molecular Genetics

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2 August 2017

volume

20

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2 August 2017

issue

2

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2 August 2017

page(s)

261-270

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Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

2 August 2017

cites work

1 reference

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

6 July 2018

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Resveratrol is not a direct activator of SIRT1 enzyme activity

6 July 2018

1 reference

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Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases

6 July 2018

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Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

6 July 2018

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CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

6 July 2018

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6 July 2018

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Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

6 July 2018

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Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice

6 July 2018

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Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons

6 July 2018

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Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration

6 July 2018

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6 July 2018

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A novel approach to screening for new neuroprotective compounds for the treatment of stroke

6 July 2018

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Inhibitors of metabolism rescue cell death in Huntington's disease models.

6 July 2018

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Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease

6 July 2018

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Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

6 July 2018

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Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

6 July 2018

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Flavonoids protect retinal ganglion cells from oxidative stress-induced death

6 July 2018

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Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

6 July 2018

1 reference

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6 July 2018

1 reference

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

6 July 2018

1 reference

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Mechanism of human SIRT1 activation by resveratrol

6 July 2018

1 reference

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Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila.

6 July 2018

1 reference

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Substrate-specific activation of sirtuins by resveratrol

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Emerging role for ERK as a key regulator of neuronal apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

A cell-based screen for drugs to treat Huntington's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Mitogen-activated protein kinases in synaptic plasticity and memory.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Oxidative neuronal injury. The dark side of ERK1/2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Can flies help humans treat neurodegenerative diseases?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Chronic activation of ERK and neurodegenerative diseases.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Resveratrol protects against global cerebral ischemic injury in gerbils

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Resveratrol increases glutamate uptake, glutathione content, and S100B secretion in cortical astrocyte cultures.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Some aspects of the in vivo neuroprotective capacity of flavonoids: bioavailability and structure-activity relationship

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

Sirtuins for healthy neurons

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3005900

A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20952447

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDQ460

1 reference

2 August 2017

1 reference

2 August 2017

1 reference