(Q35971716)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

title

Inhibitors of metabolism rescue cell death in Huntington's disease models (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

author name string

Hemant Varma

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Cindy Voisine

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Anne C Hart

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Brent R Stockwell

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

language of work or name

English

0 references

publication date

28 August 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

volume

104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

issue

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

page(s)

14525-14530

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans

4 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Selective defect of in vivo glycolysis in early Huntington's disease striatum

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Selective inhibitors of death in mutant huntingtin cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Apoptotic cascades as possible targets for inhibiting cell death in Huntington's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

IGF-I mediated survival pathways in normal and malignant cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Mitochondrial retrograde signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Clinical potential of inhibitors of survival pathways and activators of apoptotic pathways in treatment of cervical cancer: changing the apoptotic balance.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

A local mechanism mediates NAD-dependent protection of axon degeneration

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Energy balance in early-stage Huntington disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Ca2+-induced permeability transition in human lymphoblastoid cell mitochondria from normal and Huntington's disease individuals.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Neurodegenerative conditions associated with ageing: a molecular interplay?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Mitochondria: releasing power for life and unleashing the machineries of death

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Mitochondrial uncoupling as a target for drug development for the treatment of obesity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Caspases in Huntington's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Altered mitochondrial function and overgeneration of reactive oxygen species precede the induction of apoptosis by 1-O-octadecyl-2-methyl-rac-glycero-3-phosphocholine in p53-defective hepatocytes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Mitochondria make a come back

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Wild-type huntingtin protects from apoptosis upstream of caspase-3.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Bioenergetics in Huntington's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Replicating Huntington's disease phenotype in experimental animals

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Rotenone and pyruvate prevent the tert-butylhydroperoxide-induced necrosis of U937 cells and allow them to proliferate

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Isolation of human cell lines lacking mitochondrial DNA.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Neurotoxicity of sodium fluoride in rats

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Mechanism of inhibition of mitochondrial adenosine triphosphatase by dicyclohexylcarbodiimide and oligomycin: relationship to ATP synthesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

2 October 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Akt is altered in an animal model of Huntington's disease and in patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Early degenerative changes in transgenic mice expressing mutant huntingtin involve dendritic abnormalities but no impairment of mitochondrial energy production

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

The effects of dietary restriction on mitochondrial dysfunction in aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Sustained-release sodium fluoride in the treatment of the elderly with established osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0704482104

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Effect of hypoenergetic feeding on muscle oxidative phosphorylation and mitochondrial complex I-IV activities in rats.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Higher sedentary energy expenditure in patients with Huntington's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1964858

Effect of sodium fluoride on glycolysis in human erythrocytes and Ehrlich ascites tumour cells in vitro

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17726098

12 December 2020

inferred from PubMed ID database lookup

Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17726098

12 December 2020

inferred from PubMed ID database lookup

Energy supply and the shape of death in neurons and lymphoid cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17726098

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0704482104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17726098%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

17726098

1 reference