(Q34430652)

2 August 2017

title

A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations (English)

1 reference

2 August 2017

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Bryan C Dickinson

1

1 reference

2 August 2017

Michael S Packer

series ordinal

2

1 reference

2 August 2017

Ahmed H Badran

series ordinal

3

1 reference

2 August 2017

David R Liu

series ordinal

4

1 reference

2 August 2017

language of work or name

English

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publication date

30 October 2014

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2 August 2017

published in

Nature Communications

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2 August 2017

volume

5

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2 August 2017

page(s)

5352

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The discovery of asunaprevir (BMS-650032), an orally efficacious NS3 protease inhibitor for the treatment of hepatitis C virus infection

2 August 2017

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6 July 2018

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6 July 2018

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6 July 2018

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Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

6 July 2018

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Tracking the evolution of multiple in vitro hepatitis C virus replicon variants under protease inhibitor selection pressure by 454 deep sequencing

6 July 2018

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Activation of specific apoptotic caspases with an engineered small-molecule-activated protease

6 July 2018

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6 July 2018

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6 July 2018

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Design and implementation of three incoherent feed-forward motif based biological concentration sensors

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Predicting the emergence of antibiotic resistance by directed evolution and structural analysis

6 July 2018

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Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme

6 July 2018

1 reference

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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215169

Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215169

Development of drug resistance to HIV-1 protease inhibitors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215169

Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coli

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215169

Escherichia coli K-12 clones that overproduce dam methylase are hypermutable.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215169

UmuD mutagenesis protein of Escherichia coli: overproduction, purification, and cleavage by RecA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215169

A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215169

Converting trypsin to chymotrypsin: the role of surface loops

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215169

Engineering of protease variants exhibiting altered substrate specificity.

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS6352

Rational modification of enzyme catalysis by engineering surface charge

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS6352

21 January 2018

Identifiers

DOI

10.1038/NCOMMS6352

1 reference

Dimensions Publication ID

2 August 2017

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0 references

1 reference

2 August 2017

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