(Q34452837)

2 August 2017

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title

G proteins, effectors and GAPs: structure and mechanism (English)

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2 August 2017

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Sprang SR

1

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2 August 2017

1 December 1997

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Current Opinion in Structural Biology

2 August 2017

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2 August 2017

7

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2 August 2017

849-856

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2 August 2017

6

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Structure of ras proteins

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Signal transduction from multiple Ras effectors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The GTPase superfamily: a conserved switch for diverse cell functions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

How receptors talk to trimeric G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

G protein mechanisms: insights from structural analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The crystal structure of human rac1, a member of the rho-family complexed with a GTP analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Structure of the conserved GTPase domain of the signal recognition particle

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Crystal structure of the NG domain from the signal-recognition particle receptor FtsY

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Crystal structure of RhoA-GDP and its functional implications

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Structure of the GDP-Pi complex of Gly203-->Ala gialpha1: a mimic of the ternary product complex of galpha-catalyzed GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The effector interactions of p21ras

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

A hot spot of binding energy in a hormone-receptor interface

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Ras/Rap effector specificity determined by charge reversal

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Three-dimensional structure of the Ras-interacting domain of RalGDS

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Proteins regulating Ras and its relatives

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Mechanistic analysis of the observed linear free energy relationships in p21ras and related systems.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

AlF3 mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The 2.0 A crystal structure of a heterotrimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The structure of the GTPase-activating domain from p50rhoGAP

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

A new family of G-protein regulators - the RGS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Separate GTP binding and GTPase activating domains of a G alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Structure of the human ADP-ribosylation factor 1 complexed with GDP

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

An alpha to beta conformational switch in EF-Tu

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Helix unwinding in the effector region of elongation factor EF-Tu-GDP

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Crystal structure of active elongation factor Tu reveals major domain rearrangements

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2897%2980157-1

7 January 2021

10.1016/S0959-440X(97)80157-1

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

9434906