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Emerging roles of GPER in diabetes and atherosclerosis
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
25767029
retrieved
2 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Emerging roles of GPER in diabetes and atherosclerosis
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
25767029
retrieved
2 August 2017
main subject
atherosclerosis
1 reference
based on heuristic
inferred from title
author
Eric R Prossnitz
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4731095
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767029%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
author name string
Matthias Barton
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4731095
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767029%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
publication date
9 March 2015
1 reference
stated in
Europe PubMed Central
PubMed publication ID
25767029
retrieved
2 August 2017
published in
Trends in Endocrinology and Metabolism
1 reference
stated in
Europe PubMed Central
PMC publication ID
4731095
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767029%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
volume
26
1 reference
stated in
Europe PubMed Central
PMC publication ID
4731095
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767029%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
issue
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4731095
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767029%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
page(s)
185-192
1 reference
stated in
Europe PubMed Central
PMC publication ID
4731095
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767029%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
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Deciphering the GPER/GPR30-agonist and antagonists interactions using molecular modeling studies, molecular dynamics, and docking simulations
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G protein-coupled estrogen receptor protects from atherosclerosis
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G-protein estrogen receptor as a regulator of low-density lipoprotein cholesterol metabolism: cellular and population genetic studies
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6 July 2018
GPER1 (GPR30) knockout mice display reduced anxiety and altered stress response in a sex and paradigm dependent manner.
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Estrogen receptor inhibits mineralocorticoid receptor transcriptional regulatory function
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6 July 2018
GPER-targeted, 99mTc-labeled, nonsteroidal ligands demonstrate selective tumor imaging and in vivo estrogen binding.
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6 July 2018
G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis
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6 July 2018
GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts
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6 July 2018
GPER mediates activation of HIF1α/VEGF signaling by estrogens
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PubMed Central
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6 July 2018
The role of hypothalamic estrogen receptors in metabolic regulation
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6 July 2018
Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors.
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6 July 2018
Estrogenic endocrine-disrupting chemicals: molecular mechanisms of actions on putative human diseases
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6 July 2018
GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast
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PubMed Central
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6 July 2018
Niacin activates the G protein estrogen receptor (GPER)-mediated signalling.
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6 July 2018
GPR30 mediates estrogen rapid signaling and neuroprotection
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PubMed Central
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6 July 2018
Sexually dimorphic role of G protein-coupled estrogen receptor (GPER) in modulating energy homeostasis
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PubMed Central
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6 July 2018
Estrogen biology: new insights into GPER function and clinical opportunities
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6 July 2018
Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke.
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6 July 2018
G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth
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6 July 2018
2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
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6 July 2018
Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling
1 reference
stated in
PubMed Central
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6 July 2018
Regulation of vascular smooth muscle tone by adipose-derived contracting factor
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6 July 2018
Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone.
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6 July 2018
GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state
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6 July 2018
GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion
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PubMed Central
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6 July 2018
Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation
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PubMed Central
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6 July 2018
Alike but not the same: anatomic heterogeneity of estrogen receptor-mediated vasodilation.
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6 July 2018
Cholesterol and atherosclerosis: modulation by oestrogen
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6 July 2018
The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions
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PubMed Central
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6 July 2018
The role of estrogens in control of energy balance and glucose homeostasis
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6 July 2018
G protein-coupled estrogen receptor agonist improves cerebral microvascular function after hypoxia/reoxygenation injury in male and female rats
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PubMed Central
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6 July 2018
G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation
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6 July 2018
Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes
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6 July 2018
Recent advances in the rationale design of GPER ligands
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PubMed Central
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6 July 2018
Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30
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6 July 2018
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity
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6 July 2018
Mechanisms of G protein-coupled estrogen receptor-mediated spinal nociception
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6 July 2018
Functional selectivity in GPCR signaling: understanding the full spectrum of receptor conformations.
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6 July 2018
Position paper: The membrane estrogen receptor GPER--Clues and questions
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6 July 2018
Insulin-like growth factor-I regulates GPER expression and function in cancer cells
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6 July 2018
Importance of oestrogen receptors to preserve functional β-cell mass in diabetes
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6 July 2018
GPER regulates endothelin-dependent vascular tone and intracellular calcium
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6 July 2018
MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells.
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6 July 2018
Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction
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6 July 2018
Estrogen receptors and the metabolic network
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6 July 2018
The G-protein-coupled estrogen receptor GPER in health and disease
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6 July 2018
Perivascular visceral adipose tissue induces atherosclerosis in apolipoprotein E deficient mice
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6 July 2018
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity
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6 July 2018
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes
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6 July 2018
The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function
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6 July 2018
Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells
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6 July 2018
The diversity of sex steroid action: regulation of metabolism by estrogen signaling
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6 July 2018
Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors.
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6 July 2018
Minireview: Extranuclear steroid receptors: roles in modulation of cell functions
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6 July 2018
GPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice
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6 July 2018
Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis.
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6 July 2018
Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis
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6 July 2018
Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents
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6 July 2018
GPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol
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6 July 2018
Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30.
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6 July 2018
A critical review of fundamental controversies in the field of GPR30 research
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6 July 2018
GPR30/GPER1: searching for a role in estrogen physiology
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6 July 2018
The role of oestrogens in the adaptation of islets to insulin resistance
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6 July 2018
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis
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6 July 2018
17beta-estradiol prevents early-stage atherosclerosis in estrogen receptor-alpha deficient female mice
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6 July 2018
Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival
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PubMed Central
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6 July 2018
GPR30 predicts poor survival for ovarian cancer
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PubMed Central
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6 July 2018
The pancreatic beta-cell as a target of estrogens and xenoestrogens: Implications for blood glucose homeostasis and diabetes.
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6 July 2018
In vivo effects of a GPR30 antagonist
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6 July 2018
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity
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6 July 2018
G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells
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6 July 2018
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
GPR30 contributes to estrogen-induced thymic atrophy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
The cardiovascular effects of selective estrogen receptor modulators.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Oestrogens and insulin secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Lessons in estrogen biology from knockout and transgenic animals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Antidiabetic actions of estrogen: insight from human and genetic mouse models.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
Cloning of human cDNA encoding a novel heptahelix receptor expressed in Burkitt's lymphoma and widely distributed in brain and peripheral tissues
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
6 July 2018
The catecholestrogen, 2-hydroxyestradiol-17beta, acts as a G protein-coupled estrogen receptor 1 (GPER/GPR30) antagonist to promote the resumption of meiosis in zebrafish oocytes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
GPR30 mediates anorectic estrogen-induced STAT3 signaling in the hypothalamus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Sex- and age-dependent effects of Gpr30 genetic deletion on the metabolic and cardiovascular profiles of diet-induced obese mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Resveratrol inhibits K(v)2.2 currents through the estrogen receptor GPR30-mediated PKC pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Stroke increases g protein-coupled estrogen receptor expression in the brain of male but not female mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Impaired left-ventricular cardiac function in male GPR30-deficient mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
GPR30 does not mediate estrogenic responses in reproductive organs in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Virtual and biomolecular screening converge on a selective agonist for GPR30.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731095
retrieved
27 October 2018
Expression of G Protein-Coupled Receptor-30, a G Protein-Coupled Membrane Estrogen Receptor, in Oxytocin Neurons of the Rat Paraventricular and Supraoptic Nuclei
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25767029
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
ERalpha, ERbeta, and gpER: novel aspects of oestrogen receptor signalling in atherosclerosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25767029
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
GPR30 Expression Is Required for the Mineralocorticoid Receptor–Independent Rapid Vascular Effects of Aldosterone
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25767029
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TEM.2015.02.003
1 reference
stated in
Europe PubMed Central
PMC publication ID
4731095
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767029%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
PMC publication ID
4731095
1 reference
stated in
Europe PubMed Central
PMC publication ID
4731095
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767029%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
PubMed publication ID
25767029
1 reference
stated in
Europe PubMed Central
PMC publication ID
4731095
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25767029%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 June 2020
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