(Q34472032)

2 August 2017

title

Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex (English)

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2 August 2017

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Hiroko Sugiura

1

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2 August 2017

Shin Yasuda

2

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2 August 2017

Shutaro Katsurabayashi

3

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2 August 2017

Hiroyuki Kawano

4

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2 August 2017

Kentaro Endo

5

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2 August 2017

Kotaro Takasaki

6

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2 August 2017

Katsunori Iwasaki

7

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2 August 2017

Masumi Ichikawa

8

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2 August 2017

Toshiyuki Kobayashi

9

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2 August 2017

Okio Hino

10

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2 August 2017

Kanato Yamagata

11

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2 August 2017

language of work or name

English

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publication date

16 April 2015

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2 August 2017

published in

Nature Communications

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2 August 2017

volume

6

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2 August 2017

page(s)

6842

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From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology

21 January 2018

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Dendritic spine formation and synaptic function require neurobeachin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

The tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS7842

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Rheb1 is required for mTORC1 and myelination in postnatal brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

21 January 2018

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Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS7842

Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.

21 January 2018

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Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses

21 January 2018

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Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Syntenin is involved in the developmental regulation of neuronal membrane architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Activity-dependent growth of new dendritic spines is regulated by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

The ins and outs of syntenin, a multifunctional intracellular adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

EphB/syndecan-2 signaling in dendritic spine morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

A CamKIIalpha iCre BAC allows brain-specific gene inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

SynCAM, a synaptic adhesion molecule that drives synapse assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Different binding motifs in metabotropic glutamate receptor type 7b for filamin A, protein phosphatase 1C, protein interacting with protein kinase C (PICK) 1 and syntenin allow the formation of multimeric protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

CASK aberrations in male patients with Ohtahara syndrome and cerebellar hypoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Epileptic encephalopathies in early infancy with suppression-burst

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Rapamycin reduces seizure frequency in tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Everolimus treatment of refractory epilepsy in tuberous sclerosis complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Molecular cloning and characterization of Amida, a novel protein which interacts with a neuron-specific immediate early gene product arc, contains novel nuclear localization signals, and causes cell death in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Inhibitory role of endophilin 3 in receptor-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

A shared vesicular carrier allows synaptic corelease of GABA and glycine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

The effects of temperature on vesicular supply and release in autaptic cultures of rat and mouse hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

CASK and protein 4.1 support F-actin nucleation on neurexins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

7 January 2021

Spine formation and correlated assembly of presynaptic and postsynaptic molecules.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

7 January 2021

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

7 January 2021

Analysis of neurotransmitter release mechanisms by photolysis of caged Ca²⁺ in an autaptic neuron culture system

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7842

7 January 2021

Identifiers

DOI

10.1038/NCOMMS7842

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Dimensions Publication ID

2 August 2017

0 references

1016387661

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1 reference