(Q34474096)

25242287

2 August 2017

title

Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by nonlactone ligands (English)

1 reference

2 August 2017

0 references

1 reference

Christine E McInnis

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25242287%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Trevor L Schell

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25242287%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Francis M Rossi

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25242287%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

publication date

18 September 2014

1 reference

25242287

2 August 2017

published in

Chemistry and Biology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25242287%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

21

1 reference

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2 June 2020

issue

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25242287%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

1361-1369

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25242287%20AND%20SRC:MED&resulttype=core&format=json

Competition studies confirm two major barriers that can preclude the spread of resistance to quorum-sensing inhibitors in bacteria

2 June 2020

cites work

1 reference

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Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa.

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Acyl-homoserine lactone quorum sensing: from evolution to application

6 July 2018

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Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics

6 July 2018

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Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria

6 July 2018

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6 July 2018

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Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor

6 July 2018

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Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing

6 July 2018

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Thiolactone modulators of quorum sensing revealed through library design and screening

6 July 2018

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Problems with using the normal distribution--and ways to improve quality and efficiency of data analysis

6 July 2018

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A Strategy for Antagonizing Quorum Sensing

6 July 2018

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Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways

6 July 2018

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Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'.

6 July 2018

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Structural basis of acyl-homoserine lactone-dependent signaling

6 July 2018

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Small Molecules That Modulate Quorum Sensing and Control Virulence inPseudomonas aeruginosa

6 July 2018

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Synthetic biology: applications come of age

6 July 2018

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Molecular Basis for the Recognition of Structurally Distinct Autoinducer Mimics by the Pseudomonas aeruginosa LasR Quorum-Sensing Signaling Receptor

6 July 2018

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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

6 July 2018

1 reference

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Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

6 July 2018

1 reference

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Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing

6 July 2018

1 reference

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Programming gene expression with combinatorial promoters

6 July 2018

1 reference

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Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action

6 July 2018

1 reference

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Targeting virulence: a new paradigm for antimicrobial therapy

6 July 2018

1 reference

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Directed evolution of AraC for improved compatibility of arabinose- and lactose-inducible promoters

6 July 2018

1 reference

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Gene splicing and mutagenesis by PCR-driven overlap extension

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Quorum-sensing regulation in rhizobia and its role in symbiotic interactions with legumes

6 July 2018

1 reference

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Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens.

6 July 2018

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Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen.

6 July 2018

1 reference

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Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor

6 July 2018

1 reference

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Effect of sdiA on biosensors of N-acylhomoserine lactones

6 July 2018

1 reference

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Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer

6 July 2018

1 reference

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Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs

6 July 2018

1 reference

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The crystal structure of the quorum sensing protein TraR bound to its autoinducer and target DNA

6 July 2018

1 reference

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Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA

6 July 2018

1 reference

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Engineering selectivity and discrimination into ligand-receptor interfaces

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Nonenzymatic turnover of an Erwinia carotovora quorum-sensing signaling molecule

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Quorum Sensing in Bacteria

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Unnatural ligands for engineered proteins: new tools for chemical genetics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Chemical methods to interrogate bacterial quorum sensing pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Reversible signal binding by the Pseudomonas aeruginosa quorum-sensing signal receptor LasR.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Inhibition of quorum sensing in Pseudomonas aeruginosa by N-acyl cyclopentylamides

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4224638

Stereoisomers of P. aeruginosa autoinducer analog to probe the regulator binding site

27 October 2018

1 reference

12 December 2020

Bacteria-based AND logic gate: a decision-making and self-powered biosensor

1 reference

12 December 2020

Targeting virulence: can we make evolution-proof drugs?

1 reference

12 December 2020

Application of molecular docking and ONIOM methods for the description of interactions between anti-quorum sensing active (AHL) analogues and the Pseudomonas aeruginosa LasR binding site

1 reference

12 December 2020

10.1016/J.CHEMBIOL.2014.08.008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25242287%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25242287%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

25242287

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25242287%20AND%20SRC:MED&resulttype=core&format=json