(Q34474155)

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Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication

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Europe PubMed Central

PubMed publication ID

2 August 2017

Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

4

object named as

Pamela A Silver

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Alan N Engelman

5

object named as

Alan Engelman

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Europe PubMed Central

PubMed publication ID

2 August 2017

author name string

Nick Vandegraaff

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Eric Devroe

2

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Europe PubMed Central

PubMed publication ID

2 August 2017

Fanny Turlure

3

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Europe PubMed Central

PubMed publication ID

2 August 2017

language of work or name

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publication date

9 December 2005

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Europe PubMed Central

PubMed publication ID

2 August 2017

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Europe PubMed Central

PubMed publication ID

2 August 2017

346

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Europe PubMed Central

PubMed publication ID

2 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

415-426

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

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Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

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A nucleoprotein complex mediates the integration of retroviral DNA.

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HIV-1 preintegration complexes preferentially integrate into longer target DNA molecules in solution as detected by a sensitive, polymerase chain reaction-based integration assay

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Correct integration of retroviral DNA in vitro

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Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection

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Retroviral DNA integration directed by HIV integration protein in vitro

1 reference

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The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

1 reference

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The barrier-to-autointegration protein is a host factor for HIV type 1 integration

1 reference

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Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome

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Activity of recombinant HIV-1 integrase on mini-HIV DNA.

1 reference

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

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Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase

1 reference

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Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

1 reference

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Retrovirus-delivered siRNA

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Intracellular transport of human immunodeficiency virus type 1 integrase

1 reference

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Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

1 reference

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The ups and downs of gene expression and retroviral DNA integration

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HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro

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Integration of human immunodeficiency virus type 1 DNA in vitro

1 reference

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Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1.

1 reference

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Retroviral DNA integration: Structure of an integration intermediate

1 reference

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Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro

1 reference

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The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells

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Defining and assaying RNAi in mammalian cells

1 reference

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Noise amidst the silence: off-target effects of siRNAs?

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Expression profiling reveals off-target gene regulation by RNAi

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Characterization of HIV replication complexes early after cell-to-cell infection

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Relationship of avian retrovirus DNA synthesis to integration in vitro

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A previously unidentified host protein protects retroviral DNA from autointegration

1 reference

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The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes

1 reference

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Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase

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LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

1 reference

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Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase

1 reference

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Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication

1 reference

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LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

1 reference

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Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75

1 reference

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Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions

1 reference

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Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

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Degradation of HIV-1 integrase by the N-end rule pathway

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Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus

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Molecular biology of HMGA proteins: hubs of nuclear function

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HIV-1 integration in the human genome favors active genes and local hotspots

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LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes

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Recombinant human immunodeficiency virus type 1 integrase exhibits a capacity for full-site integration in vitro that is comparable to that of purified preintegration complexes from virus-infected cells

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Efficient concerted integration by recombinant human immunodeficiency virus type 1 integrase without cellular or viral cofactors

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Structural variation in PWWP domains

1 reference

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The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?

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Regulatory mechanisms by which barrier-to-autointegration factor blocks autointegration and stimulates intermolecular integration of Moloney murine leukemia virus preintegration complexes

1 reference

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Human cell proteins and human immunodeficiency virus DNA integration

1 reference

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Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering

1 reference

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Transcription start regions in the human genome are favored targets for MLV integration

1 reference

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HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro

1 reference

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based on heuristic

inferred from DOI database lookup

Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells

1 reference

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based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.VIROL.2005.11.022

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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