(Q34480379)

2 August 2017

title

Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH (English)

1 reference

2 August 2017

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Solomon Halbert Snyder

9

object named as

Solomon H Snyder

1 reference

2 August 2017

Byoung-Il Bae

1

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Michael R. Hayden

object named as

Michael R Hayden

5

0 references

Christopher A Ross

6

object named as

Christopher A Ross

1 reference

2 August 2017

4

Cheryl L Wellington

1 reference

2 August 2017

10

Akira Sawa

1 reference

2 August 2017

7

Hyo Chol Ha

1 reference

2 August 2017

3

Matthew B Cascio

1 reference

2 August 2017

Makoto R Hara

2

1 reference

2 August 2017

Xiao-Jiang Li

8

1 reference

2 August 2017

language of work or name

English

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publication date

21 February 2006

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Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

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2 August 2017

volume

103

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2 August 2017

issue

9

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2 August 2017

page(s)

3405-3409

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S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Polyglutamine expansion of huntingtin impairs its nuclear export

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Mechanisms of neuronal cell death in Huntington's disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Interaction of Huntington disease protein with transcriptional activator Sp1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Mechanisms for neuronal cell death and dysfunction in Huntington's disease: pathological cross-talk between the nucleus and the mitochondria?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Characterization of human homologs of the Drosophila seven in absentia (sina) gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1413934

Nuclear targeting of mutant Huntingtin increases toxicity

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

Brain glyceraldehyde-3-phosphate dehydrogenase activity in human trinucleotide repeat disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington’s disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

Alteration of nuclear glyceraldehyde-3-phosphate dehydrogenase structure in Huntington's disease fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

Reduction of Purkinje cell pathology in SCA1 transgenic mice by p53 deletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0511316103

21 January 2018

Identifiers

DOI

10.1073/PNAS.0511316103

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference