(Q34487152)

2 August 2017

title

Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme (English)

1 reference

2 August 2017

1 reference

Antonio Ariza

1

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Ian Eggleston

Ian M Eggleston

6

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Charles S Bond

Charles S Bond

8

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Alan Fairlamb

Alan H Fairlamb

7

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Tim J. Vickers

2

Tim J Vickers

1 reference

2 August 2017

3

Neil Greig

1 reference

2 August 2017

Kirsten A Armour

4

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2 August 2017

Mark J Dixon

5

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2 August 2017

language of work or name

English

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publication date

1 February 2006

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2 August 2017

published in

Molecular Microbiology

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2 August 2017

volume

59

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2 August 2017

issue

4

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2 August 2017

page(s)

1239-1248

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Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I.

2 August 2017

cites work

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Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue

21 January 2018

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21 January 2018

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21 January 2018

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Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation

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Errors in protein structures

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Active site of trypanothione reductase. A target for rational drug design.

21 January 2018

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Glyoxalase II of African trypanosomes is trypanothione-dependent

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Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stress

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Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development

21 January 2018

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21 January 2018

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Distinct classes of glyoxalase I: metal specificity of the Yersinia pestis, Pseudomonas aeruginosa and Neisseria meningitidis enzymes

21 January 2018

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Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.

21 January 2018

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21 January 2018

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21 January 2018

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A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major

21 January 2018

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Synthesis of the trypanosomatid metabolites trypanothione, and N 1-mono- and N 8-mono-glutathionylspermidine

21 January 2018

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21 January 2018

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COCI

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10.1111/J.1365-2958.2006.05022.X

5 March 2023

Identifiers

DOI

1 reference

2 August 2017

1 reference