(Q34493889)

2 August 2017

title

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity (English)

1 reference

2 August 2017

0 references

Adam B Roberts

2

0 references

Sara K O'Neal

object named as

Sara K O'Neal

9

0 references

Matthew R Redinbo

21

object named as

Matthew R Redinbo

1 reference

2 August 2017

Bret D Wallace

1

1 reference

2 August 2017

Rebecca M Pollet

3

1 reference

2 August 2017

James D Ingle

4

1 reference

2 August 2017

Kristen A Biernat

5

1 reference

2 August 2017

Samuel J Pellock

6

1 reference

2 August 2017

Madhu Kumar Venkatesh

7

1 reference

2 August 2017

Leah Guthrie

8

1 reference

2 August 2017

Sara J Robinson

10

1 reference

2 August 2017

Makani Dollinger

11

1 reference

2 August 2017

Esteban Figueroa

12

1 reference

2 August 2017

Sarah R McShane

13

1 reference

2 August 2017

Rachel D Cohen

14

1 reference

2 August 2017

Jian Jin

15

1 reference

2 August 2017

Stephen V Frye

16

1 reference

2 August 2017

William C Zamboni

17

1 reference

2 August 2017

Charles Pepe-Ranney

18

1 reference

2 August 2017

Sridhar Mani

19

1 reference

2 August 2017

Libusha Kelly

20

1 reference

2 August 2017

publication date

10 September 2015

1 reference

2 August 2017

published in

Chemistry and Biology

1 reference

2 August 2017

volume

22

1 reference

2 August 2017

issue

9

1 reference

2 August 2017

page(s)

1238-1249

1 reference

The microbiota, chemical symbiosis, and human disease

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Old drug new use--amoxapine and its metabolites as potent bacterial β-glucuronidase inhibitors for alleviating cancer drug toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

High resolution crystal structure of human β-glucuronidase reveals structural basis of lysosome targeting

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Understanding and modulating mammalian-microbial communication for improved human health

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Molecular Insights into Microbial -Glucuronidase Inhibition to Abrogate CPT-11 Toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

The human microbiome is a source of therapeutic drug targets

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Gut microbiomes of Malawian twin pairs discordant for kwashiorkor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Multiple NSAID-induced hits injure the small intestine: underlying mechanisms and novel strategies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Antibiotics in early life alter the murine colonic microbiome and adiposity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Structure, function and diversity of the healthy human microbiome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Host-gut microbiota metabolic interactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Microbiome and malignancy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Understanding the role of gut microbiome-host metabolic signal disruption in health and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

A metagenomic β-glucuronidase uncovers a core adaptive function of the human intestinal microbiome.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

A review of the gastrointestinal safety data--a gastroenterologist's perspective

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Nonsteroidal anti-inflammatory drugs and lower gastrointestinal complications

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

An obesity-associated gut microbiome with increased capacity for energy harvest

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Systemic therapy for metastatic colorectal cancer: current options, current evidence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

The discovery and development of antiinflammatory drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Lessons learned from the irinotecan metabolic pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Mortality associated with irinotecan plus bolus fluorouracil/leucovorin: summary findings of an independent panel

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

In vitro evolution of beta-glucuronidase into a beta-galactosidase proceeds through non-specific intermediates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Clinical pharmacology and pharmacodynamics of irinotecan. A review

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Severe chemotherapy-induced diarrhea in patients with colorectal cancer: a cost of illness analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

A functional screen identifies lateral transfer of beta-glucuronidase (gus) from bacteria to fungi.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Saccharic acid 1.4-lactone protects against CPT-11-induced mucosa damage in rats

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4575908

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26364932

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26364932

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2015.08.005

1 reference

2 August 2017

1 reference

2 August 2017

1 reference