(Q34504188)

2 August 2017

title

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia (English)

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2 August 2017

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Andrew W Roberts

1

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William G Wierda

18

object named as

William G Wierda

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2 August 2017

Matthew S Davids

2

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2 August 2017

John M Pagel

3

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Brad S Kahl

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Soham D Puvvada

5

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John F Gerecitano

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Thomas J Kipps

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Mary Ann Anderson

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Jennifer R Brown

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Lori Gressick

10

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2 August 2017

Shekman Wong

11

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Martin Dunbar

12

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Ming Zhu

13

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Monali B Desai

14

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Elisa Cerri

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Sari Heitner Enschede

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Rod A Humerickhouse

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John F Seymour

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2 August 2017

language of work or name

English

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publication date

6 December 2015

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The New England Journal of Medicine

2 August 2017

published in

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2 August 2017

volume

374

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2 August 2017

issue

4

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2 August 2017

page(s)

311-322

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Dose escalation methods in phase I cancer clinical trials

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cites work

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12 December 2020

Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies

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12 December 2020

Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group

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Risk categories and refractory CLL in the era of chemoimmunotherapy

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12 December 2020

Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia: justification for risk-adapted therapy

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12 December 2020

Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia

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12 December 2020

The tumor lysis syndrome

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12 December 2020

Bendamustine combined with rituximab in patients with relapsed and/or refractory chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group

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Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL.

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12 December 2020

miR-15 and miR-16 induce apoptosis by targeting BCL2

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12 December 2020

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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12 December 2020

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

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12 December 2020

Salvage outcomes in patients with first relapse after fludarabine, cyclophosphamide, and rituximab for chronic lymphocytic leukemia: the French intergroup experience

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12 December 2020

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

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12 December 2020

Apoptosis therapy: driving cancers down the road to ruin

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12 December 2020

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

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12 December 2020

Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia

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12 December 2020

Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study

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12 December 2020

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

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12 December 2020

Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome

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12 December 2020

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

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12 December 2020

Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia

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12 December 2020

Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab)

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12 December 2020

Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia.

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12 December 2020

Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib

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12 December 2020

Relevance of the immunoglobulin VH somatic mutation status in patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab (FCR) or related chemoimmunotherapy regimens

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12 December 2020

Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic Leukemia

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12 December 2020

Idelalisib and rituximab in relapsed chronic lymphocytic leukemia

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12 December 2020

Programmed anuclear cell death delimits platelet life span.

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12 December 2020

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.

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12 December 2020

Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia

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12 December 2020

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

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12 December 2020

Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib

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12 December 2020

Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib

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12 December 2020

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

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12 December 2020

Identifiers

DOI

10.1056/NEJMOA1513257

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2 August 2017

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