(Q34505760)

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Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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1 reference

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author name string

Ingo Flamme

1

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Felix Oehme

2

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Peter Ellinghaus

3

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Mario Jeske

4

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

Jörg Keldenich

5

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Europe PubMed Central

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2 August 2017

Uwe Thuss

6

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Europe PubMed Central

PubMed publication ID

2 August 2017

language of work or name

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publication date

13 November 2014

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Europe PubMed Central

PubMed publication ID

2 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

e111838

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

copyright license

Creative Commons Attribution 4.0 International

13 November 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism

1 reference

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7 July 2018

Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses

1 reference

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7 July 2018

Effects of recombinant human erythropoietin on resistance artery endothelial function in stage 4 chronic kidney disease

1 reference

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7 July 2018

Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Hypertension management: rationale for triple therapy based on mechanisms of action

1 reference

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7 July 2018

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis

1 reference

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7 July 2018

Dose of erythropoiesis-stimulating agents and adverse outcomes in CKD: a metaregression analysis

1 reference

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7 July 2018

Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

1 reference

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7 July 2018

Oxygen sensing, homeostasis, and disease

1 reference

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7 July 2018

HIF prolyl hydroxylase inhibitors for anemia

1 reference

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7 July 2018

The effect of altitude change on anemia treatment response in hemodialysis patients

1 reference

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7 July 2018

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

1 reference

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7 July 2018

The HIF pathway and erythrocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Hepcidin and disorders of iron metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

1 reference

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7 July 2018

Reactivation of hepatic EPO synthesis in mice after PHD loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Regulation of human metabolism by hypoxia-inducible factor

1 reference

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7 July 2018

Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha

1 reference

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7 July 2018

Hyporesponsiveness to erythropoietin: causes and management

1 reference

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7 July 2018

Arterial hypertension induced by erythropoietin and erythropoiesis-stimulating agents (ESA).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

The effect of altitude on dosing and response to erythropoietin in ESRD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Erythropoiesis-stimulating agent hyporesponsiveness.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

The role of the kidney in blood volume regulation: the kidney as a regulator of the hematocrit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

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Pathogenesis of renal anemia

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7 July 2018

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

1 reference

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7 July 2018

Integration of oxygen signaling at the consensus HRE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Anemia of chronic disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Oxygen sensing by HIF hydroxylases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

1 reference

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Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

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7 July 2018

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

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7 July 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

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7 July 2018

Induction of HIF-1alpha in response to hypoxia is instantaneous

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230943

7 July 2018

Molecular basis of hypoxia-induced erythropoietin expression.

1 reference

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7 July 2018

Erythropoietin response to acute hypobaric or anaemic hypoxia in gentamicin-administered rats

1 reference

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7 July 2018

Erythropoietin and systemic hypertension.

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7 July 2018

Protracted anemia associated with chronic, relapsing systemic inflammation induced by arthropathic peptidoglycan-polysaccharide polymers in rats

1 reference

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7 July 2018

Effect of recombinant human erythropoietin on new anaemic model rats induced by gentamicin

1 reference

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7 July 2018

A nonradioactive 96-well plate assay for the detection of hypoxia-inducible factor prolyl hydroxylase activity

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21 January 2018

Comparing the global mRNA expression profile of human atrial and ventricular myocardium with high-density oligonucleotide arrays.

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21 January 2018

Giving anemia a boost with inhibitors of prolyl hydroxylase.

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21 January 2018

Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells.

1 reference

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High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

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21 January 2018

Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney

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Regulation of erythropoietin production is related to proximal tubular function

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Effects of reduction of renal mass on renal oxygen tension and erythropoietin production in the rat

1 reference

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1 reference

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Sensitive ELISA for mouse erythropoietin

1 reference

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A modular polycistronic expression system for overexpressing protein complexes in Escherichia coli

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Plasma erythropoietin in men and mice during acclimatization to different altitudes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

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based on heuristic

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Erythropoietin production in patients with chronic renal failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of gentamicin nephrotoxicity between rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of hypoxia on growth factor expression in the rat kidney in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

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based on heuristic

inferred from PubMed ID database lookup

Update on clinical practice recommendations and new therapeutic modalities for treating anemia in patients with chronic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

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based on heuristic

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Erythropoiesis-stimulating agents--time for a reevaluation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25392999

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based on heuristic

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Identifiers

10.1371/JOURNAL.PONE.0111838

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

2014PLoSO...9k1838F

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

ResearchGate publication ID

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